全科医学临床与教育
全科醫學臨床與教育
전과의학림상여교육
CLINICAL EDUCATION OF GENERAL PRACTICE
2014年
3期
263-265
,共3页
蔡叶樨%张红河%倪慧群%徐庆嵩
蔡葉樨%張紅河%倪慧群%徐慶嵩
채협서%장홍하%예혜군%서경숭
宫颈癌%25-羟基维生素D%白介素6%白介素17
宮頸癌%25-羥基維生素D%白介素6%白介素17
궁경암%25-간기유생소D%백개소6%백개소17
cervical cancer%25(OH) vitamin D%interleukin 6%interleukin 17
目的：探讨宫颈癌患者Th17细胞相关因子与25-羟基维生素D检测的临床价值。方法收集宫颈癌患者68例，其中腺癌28例、鳞状细胞癌40例，选取年龄与其相匹配的50例健康体检者作为对照组。分析25羟维生素D与白介素17（IL-17）、白介素6（IL-6）在各组间的差异及其相关性。结果宫颈癌患者血浆25-羟基维生素D浓度为（24.50±6.80）ng/ml，低于健康对照组（35.10±8.70）ng/ml，宫颈癌患者血浆IL-17浓度为550（350，705）ng/L，IL-6浓度为480（390，620）ng/L，均低于健康对照组，差异有统计学意义（P均＜0.05）；腺癌患者血浆25-羟基维生素D、IL-17、IL-6浓度与鳞状细胞癌患者比较，差异无统计学意义（P＞0.05）；宫颈癌患者血浆IL-6、IL-17与25-羟基维生素D存在相关性（r分别=0.37、0.40， P均＜0.05）。结论宫颈癌患者血浆25-羟基维生素D与Th17细胞相关因子浓度检测对治疗和预后监测具有一定临床价值。
目的：探討宮頸癌患者Th17細胞相關因子與25-羥基維生素D檢測的臨床價值。方法收集宮頸癌患者68例，其中腺癌28例、鱗狀細胞癌40例，選取年齡與其相匹配的50例健康體檢者作為對照組。分析25羥維生素D與白介素17（IL-17）、白介素6（IL-6）在各組間的差異及其相關性。結果宮頸癌患者血漿25-羥基維生素D濃度為（24.50±6.80）ng/ml，低于健康對照組（35.10±8.70）ng/ml，宮頸癌患者血漿IL-17濃度為550（350，705）ng/L，IL-6濃度為480（390，620）ng/L，均低于健康對照組，差異有統計學意義（P均＜0.05）；腺癌患者血漿25-羥基維生素D、IL-17、IL-6濃度與鱗狀細胞癌患者比較，差異無統計學意義（P＞0.05）；宮頸癌患者血漿IL-6、IL-17與25-羥基維生素D存在相關性（r分彆=0.37、0.40， P均＜0.05）。結論宮頸癌患者血漿25-羥基維生素D與Th17細胞相關因子濃度檢測對治療和預後鑑測具有一定臨床價值。
목적：탐토궁경암환자Th17세포상관인자여25-간기유생소D검측적림상개치。방법수집궁경암환자68례，기중선암28례、린상세포암40례，선취년령여기상필배적50례건강체검자작위대조조。분석25간유생소D여백개소17（IL-17）、백개소6（IL-6）재각조간적차이급기상관성。결과궁경암환자혈장25-간기유생소D농도위（24.50±6.80）ng/ml，저우건강대조조（35.10±8.70）ng/ml，궁경암환자혈장IL-17농도위550（350，705）ng/L，IL-6농도위480（390，620）ng/L，균저우건강대조조，차이유통계학의의（P균＜0.05）；선암환자혈장25-간기유생소D、IL-17、IL-6농도여린상세포암환자비교，차이무통계학의의（P＞0.05）；궁경암환자혈장IL-6、IL-17여25-간기유생소D존재상관성（r분별=0.37、0.40， P균＜0.05）。결론궁경암환자혈장25-간기유생소D여Th17세포상관인자농도검측대치료화예후감측구유일정림상개치。
Objective To investigate plasma T helper cell 17 cytokine and 25 (OH) vitamin D in patients with cervical cancer and its clinical value. Methods Sixty eight cases with cervical cancer were enrolled, including 28 cases of adeno-carcinoma, 40 cases squamous cell carcinoma. Selected age matched 50 healthy volunteers as a control group. 25(OH) vi-tamin D and T helper cell 17 cytokine in the differences among the groups and their correlation were analyzed. Results Cervical cancer patients plasma 25(OH) vitamin D concentration were(24.50±6.80)ng/ml, lower than the healthy control group (35.10 ±8.70) ng/ml, cervical cancer patients plasma IL-17, IL-6 concentrations were 550 (350,705)ng/L,480 (390,620)ng/L, lower than the healthy control group, the difference was statistically significant(P<0.05); adenocarcino-ma patients plasma 25(OH) vitamin D, IL-17, IL-6 concentrations was not statistically significant difference with patients of squamous cell carcinoma (P>0.05), there was correlation of plasma IL-17, IL-6 and 25 (OH) vitamin D in patients with cervical cancer (r=0.37, 0.40, P<0.05). Conclusions Plasma 25 (OH) vitamin D and IL-17, IL-6 concentration detection are helpful for monitoring the treatment and prognosis of patients with cervical cancer.
