CAJ | 학술논문

目的：探讨γ干扰素诱导蛋白10（IP-10）对糖尿病合并活动性肺结核的临床诊断价值。方法选取糖尿病合并活动性肺结核病例（A组）24例、活动性肺结核病例（B组）34例、非结核肺部疾病病例（C组）10例、糖尿病（D组）10例、健康志愿者（E组）12例，检测血IP-10水平。结果 A组IP-10水平均高于其他4组（P均＜0．01）；IP-10诊断活动性肺结核的曲线下面积为0．872，临界值为146．80 ng/L，敏感性和特异性分别为65．5％和93．7％。结论血IP-10在糖尿病合并活动性肺结核患者中显著增高，可作为其诊断的辅助指标。
목적：탐토γ간우소유도단백10（IP-10）대당뇨병합병활동성폐결핵적림상진단개치。방법선취당뇨병합병활동성폐결핵병례（A조）24례、활동성폐결핵병례（B조）34례、비결핵폐부질병병례（C조）10례、당뇨병（D조）10례、건강지원자（E조）12례，검측혈IP-10수평。결과 A조IP-10수평균고우기타4조（P균＜0．01）；IP-10진단활동성폐결핵적곡선하면적위0．872，림계치위146．80 ng/L，민감성화특이성분별위65．5％화93．7％。결론혈IP-10재당뇨병합병활동성폐결핵환자중현저증고，가작위기진단적보조지표。
Objective To investigate the value of interferon -inducible protein-10 (IP-10) in clinical diagnosis of diabetes and active tuberculosis .Metho ds 24 patients with diabetes and active tuberculosis (group A), 34 patients with active tuberculosis (group B), 10 patients with non -tuberculosis pulmonary disease (group C), 10 patients with diabetes (group D), and 12 healthy volunteers (group E) were enrolled for serum IP -10 detection and statistical analy-sis.Results The serum IP-10 concentrations in group A were significantly higher than the other 4 groups (P<0.01). In addition, when diagnosing active tuberculosis with IP -10, the area under curve (AUC) was 0.872, the critical value was 146.80 ng/L.The sensitivity and specificity were 65.5%and 93.7%, respectively.Conclusions Serum IP-10 is significantly increased in patients with diabetes and active tuberculosis , thus, IP-10 can be used as an auxiliary index in the diagnosis of diabetes and active tuberculosis .