CAJ | 학술논문

目的：分析肺上皮样血管内皮细胞瘤（ PEH）临床病理特点，加强对该疾病的认识，提高诊断水平。方法结合本科诊断的1例PEH患者的临床病理资料和文献复习，分析该病的临床病理特点和鉴别诊断。结果 PEH影像学表现为双肺多发性结节。组织学表现为上皮样细胞构成的结节中心硬化或呈淀粉样变，结节周边富细胞，瘤细胞轻到中度异型，胞质内见原始血管腔。瘤细胞呈巢状伸入周围的肺泡腔生长。免疫组化提示瘤细胞主要表达CD31、CD34、、Ⅷ因子、Vimentin、CK等标记物。鉴别诊断主要包括硬化性血管瘤、上皮样血管瘤、上皮样血管肉瘤、上皮样肉瘤等。结论正确的诊断与鉴别诊断PEH需要结合影像学检查、组织学观察和免疫组织化学分析等方法。
목적：분석폐상피양혈관내피세포류（ PEH）림상병리특점，가강대해질병적인식，제고진단수평。방법결합본과진단적1례PEH환자적림상병리자료화문헌복습，분석해병적림상병리특점화감별진단。결과 PEH영상학표현위쌍폐다발성결절。조직학표현위상피양세포구성적결절중심경화혹정정분양변，결절주변부세포，류세포경도중도이형，포질내견원시혈관강。류세포정소상신입주위적폐포강생장。면역조화제시류세포주요표체CD31、CD34、、Ⅷ인자、Vimentin、CK등표기물。감별진단주요포괄경화성혈관류、상피양혈관류、상피양혈관육류、상피양육류등。결론정학적진단여감별진단PEH수요결합영상학검사、조직학관찰화면역조직화학분석등방법。
Objective:To describe the clinical pathological charahteristics of pulmonary epithelioid haemangioendothelio-ma( PEH)and strengthen the understanding of the disease and improve the diagnostic level. Methods:With a case report and review of the related literature,the cliniacal pathologic charahteristics of PEH and differential diagnosis were de-scribed. Results:The imaging characteristic of PEH was muttiple nodules in both sides of the lung. The histological mani-festations of PEH showed a hardening or amyloidosis in the center of the nodule constituted with epithelioid cells,and rich cells aroud the nodule,and mild-moderate atypia of tumor cells,and the original blood vessel lumen in the cytoplasm. The nests of tumor cells grow into the alveolar aroud the nodule. Immunohistochemical analysis showed that tumor cells mainly express CD31,CD34,Ⅷfactor,Vimentin,CK and other markers. Conclusion:Correct diagnosis and differential diagnosis a-bout PEH requires a combination of imaging studies,histological observation and immunohistochemical analysis and other methods.