CAJ | 학술논문

目的：检测基质金属蛋白酶9（MMP-9）在肾细胞癌中的表达，探讨其与患者临床预后的相关性。方法肾癌患者150例，另设癌旁组30例和健康对照组20例，利用免疫组织化学染色检测肾癌组织，癌旁组织及正常肾脏组织中MMP-9的表达。并联系相关随访记录。探讨两者之间的相关性。结果（1）MMP-9在肾癌组织中高表达，肾肿瘤旁组织及正常肾脏组织中低表达，肾癌组与肾肿瘤旁组织及正常肾脏组织分别比较，均有显著差异（P﹤0.05）。（2）MMP-9表达与肾癌病人的年龄，肿瘤大小没有相关性（P=0.412；P=0.083），与肿瘤分期、分级及淋巴结转移成正相关（ P=0.009；P=0.017；P=0.004）。伴有MMP-9高表达的肾癌患者无复发生存率明显低于MMP-9低表达的患者（ P﹤0.001）。结论 MMP-9在肾癌组织中呈持续高表达，与肾癌患者的临床病理指标，生物学行为和预后密切相关，是评估肾癌进展，不良预后的重要指标。
목적：검측기질금속단백매9（MMP-9）재신세포암중적표체，탐토기여환자림상예후적상관성。방법신암환자150례，령설암방조30례화건강대조조20례，이용면역조직화학염색검측신암조직，암방조직급정상신장조직중MMP-9적표체。병련계상관수방기록。탐토량자지간적상관성。결과（1）MMP-9재신암조직중고표체，신종류방조직급정상신장조직중저표체，신암조여신종류방조직급정상신장조직분별비교，균유현저차이（P﹤0.05）。（2）MMP-9표체여신암병인적년령，종류대소몰유상관성（P=0.412；P=0.083），여종류분기、분급급림파결전이성정상관（ P=0.009；P=0.017；P=0.004）。반유MMP-9고표체적신암환자무복발생존솔명현저우MMP-9저표체적환자（ P﹤0.001）。결론 MMP-9재신암조직중정지속고표체，여신암환자적림상병리지표，생물학행위화예후밀절상관，시평고신암진전，불량예후적중요지표。
Objective:To investigate the expression of matrix metalloproteinase-9( MMP-9 )in renal cell carcinoma and determine its clinical significances. Methods:The samples were divided into 3 groups:renal cell carcinoma group(150 cases),paracarcinoma group(30 cases)and normal kidney group(20 cases). The expression of MMP-9 in renal cell carcinoma tissues,paracarcinoma tissues and normal kidney tissues were detected by immunohistochemistry. Results:The expression of MMP-9 proteins in renal cell carcinoma tissues were significantly stronger than paracarcinoma tissues and normal kidney tissues,and the differences were significant(P﹤0. 05). The expression of MMP-9 in renal cell carcinoma tissues was positively correlated with tumor stage,grade and lymph node metastasis(P=0. 009;P=0. 017;P=0. 004). The expression of MMP-9 had no relation with the patients’age and tumor size(P=0. 412;P=0. 083). The patients with high expression of MMP-9 had a significantly lower recurrence-free survival rate than patients with low expression of MMP-9(P﹤0. 001). Conclusions:The expression of MMP-9 is closely correlated with clinical characteristics,biologi-cal behaviors and prognosis. The detection of MMP-9 can serve as an important marker for early diagnosis,development and prognosis of renal cell carcinoma.