CAJ | 학술논문

目的了解宫颈糜烂患者沙眼衣原体(CT)和解脲支原体(UU)感染状况,探讨宫颈糜烂与CT、UU感染的关系.方法应用免疫层析法和培养法,对562例宫颈糜烂患者(观察组)和218例宫颈正常者(对照组)的宫颈分泌物进行CT和UU的检测,对UU培养测定结果阳性者行药敏试验.结果观察组患者CT、UU以及CT+UU混昆合感染阳性率分别为20.11％、42.35％和9.61％;对照组CT、UU以及CT+UU混合感染阳性率分别为6.42％、12.39％和0.92％,两组比较差异有统计学意义(P＜0.05).中度与重度宫颈糜烂间CT、UU以及CT+UU混合感染阳性率差异无统计学意义(P＞0.05),而中、重度患者与轻度间差异有统计学意义(P＜0.05).UU对9种药物敏感性最高的是交沙霉素(91.78％),其次是原始霉素(84.25％);耐药性最高的是环丙沙星(85.96％),其次是氧氟沙星(73.29％).结论 CT和UU感染与宫颈糜烂的发生及糜烂程度存在密切相关.UU对常用抗生素存在不同程度的耐药性,临床应选敏感有效的抗生素治疗感染.
목적 료해궁경미란환자사안의원체(CT)화해뇨지원체(UU)감염상황,탐토궁경미란여CT、UU감염적관계.방법 응용면역층석법화배양법,대562례궁경미란환자(관찰조)화218례궁경정상자(대조조)적궁경분비물진행CT화UU적검측,대UU배양측정결과양성자행약민시험.결과 관찰조환자CT、UU이급CT+UU혼곤합감염양성솔분별위20.11％、42.35％화9.61％;대조조CT、UU이급CT+UU혼합감염양성솔분별위6.42％、12.39％화0.92％,량조비교차이유통계학의의(P＜0.05).중도여중도궁경미란간CT、UU이급CT+UU혼합감염양성솔차이무통계학의의(P＞0.05),이중、중도환자여경도간차이유통계학의의(P＜0.05).UU대9충약물민감성최고적시교사매소(91.78％),기차시원시매소(84.25％);내약성최고적시배병사성(85.96％),기차시양불사성(73.29％).결론 CT화UU감염여궁경미란적발생급미란정도존재밀절상관.UU대상용항생소존재불동정도적내약성,림상응선민감유효적항생소치료감염.
Objective To investigate the current situation of infection of chlamydia trachomatis (CT) and ureaplasma urealyticum (UU) in patients with cervical erosion,and explore the relationship between the infection of CT and UU and cervical erosion.Methods Immunochromatography and culturing method were used to detect the cervical secretion obtained from 562 cases of cervical erosion patients (the observation group) and 218 healthy controls (the control group) for the CT and UU.The drug susceptibility testing was performed for the patients' with mycoplasma tested positive.Results In the observation group,the positive rates of CT,UU and both were 20.11％,42.35％ and 9.61％ respectively,which were higher than 6.42％,12.39％ and 0.92％ in the control group,the difference was significantly different (P ＜ 0.05).The difference of the positive rate between moderate cervical erosion and severe cervical erosion was not significantly different (P ＞ 0.05),while the positive rates of CT,UU and both were significantly different (P ＜ 0.05) when mild cervical erosion respectively compared with moderate cervical erosion and severe cervical erosion.The highest susceptibility rate of UU to 9 kinds of antimicrobial agents was josamycin (91.78％),the second was pristinamycin (84.25％); the highest resistant rate of UU was ciprofloxacin (85.96％),the second was ofloxacin (73.29％).Conclusion The infection of CT and UU has intimate correlation with the occurrence of cervical erosion and the extent of erosion.Varying degrees of drug resistance of UU can be found in clinical common use antibiotics,and the sensitive and effective antibiotics should be chosen to treat cervical erosion infection of UU.