胃肠病学
胃腸病學
위장병학
CHINESE JOURNAL OF GASTROENTEROLOGY
2014年
5期
305-308
,共4页
胆汁反流性胃炎%十二指肠胃反流%胆汁酸类和盐类%诊断%治疗
膽汁反流性胃炎%十二指腸胃反流%膽汁痠類和鹽類%診斷%治療
담즙반류성위염%십이지장위반류%담즙산류화염류%진단%치료
Bile Reflux Gastritis%Duodenogastric Reflux%Bile Acids and Salts%Diagnosis%Therapy
胆汁反流性胃炎（BRG）是由过量十二指肠胃反流（DGR）引起的化学性胃病。病理性 DGR 系由幽门解剖结构异常或胃窦、幽门十二指肠运动失调所致，反流的胆汁酸可诱导胃黏膜细胞凋亡，高浓度胆汁酸是引起胃黏膜肠化生的重要因素。本文拟对 DGR 的发生机制、胆汁酸对胃黏膜的损伤作用以及 BRG 诊断和治疗方面的研究进展作一综述。
膽汁反流性胃炎（BRG）是由過量十二指腸胃反流（DGR）引起的化學性胃病。病理性 DGR 繫由幽門解剖結構異常或胃竇、幽門十二指腸運動失調所緻，反流的膽汁痠可誘導胃黏膜細胞凋亡，高濃度膽汁痠是引起胃黏膜腸化生的重要因素。本文擬對 DGR 的髮生機製、膽汁痠對胃黏膜的損傷作用以及 BRG 診斷和治療方麵的研究進展作一綜述。
담즙반류성위염（BRG）시유과량십이지장위반류（DGR）인기적화학성위병。병이성 DGR 계유유문해부결구이상혹위두、유문십이지장운동실조소치，반류적담즙산가유도위점막세포조망，고농도담즙산시인기위점막장화생적중요인소。본문의대 DGR 적발생궤제、담즙산대위점막적손상작용이급 BRG 진단화치료방면적연구진전작일종술。
Bile reflux gastritis (BRG)has been recognized as a chemical gastropathy due to excessive duodenogastric reflux (DGR).Abnormalities in pyloric anatomic structure,as well as antropyloric and duodenal dysmotility are considered to be implicated in the occurrence of pathologic DGR.Bile acid may induce apoptosis of gastric mucosal cells,and high concentration of bile acid plays a crucial role in the induction of intestinal metaplasia in stomach.In this review article, advances in study on BRG,including the mechanisms of DGR,the pathogenic effect of bile acid on gastric mucosa,and the diagnosis and treatment of BRG were summarized.
