CAJ | 학술논문

通过土鳖虫粉高、中、低剂量饲喂高脂血症家兔，探讨土鳖虫粉对高脂血症家兔血脂指标和肝脏指数的影响。选用体质健康雌性肉兔150只，随机分为空白对照组、模型对照组和高、中、低剂量组，三个剂量组分别按照0.45、0.30和0.15 g·kg-1给药量饲喂高脂血症家兔，并于造模结束时、给药第10天、第20天、第30天空腹称重，心脏采血，检测血清胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白含量，屠宰后取其肝脏并称重，计算肝脏指数。结果表明，高、中、低剂量土鳖虫粉均能不同程度降低血清胆固醇、甘油三脂、低密度脂蛋白含量和肝脏指数，并升高血清高密度脂蛋白的含量，但与模型组比，高、中剂量组差异显著（P<0.05），低剂量组差异不显著；与空白组比，高、中剂量组差异不显著，低剂量组TC、TG含量和肝脏指数差异显著（P<0.05）。结果表明，土鳖虫粉对高脂血症家兔具有调节和降低血脂水平的作用，最适宜剂量选用中剂量0.30 g·kg-1。
통과토별충분고、중、저제량사위고지혈증가토，탐토토별충분대고지혈증가토혈지지표화간장지수적영향。선용체질건강자성육토150지，수궤분위공백대조조、모형대조조화고、중、저제량조，삼개제량조분별안조0.45、0.30화0.15 g·kg-1급약량사위고지혈증가토，병우조모결속시、급약제10천、제20천、제30천공복칭중，심장채혈，검측혈청담고순、감유삼지、저밀도지단백、고밀도지단백함량，도재후취기간장병칭중，계산간장지수。결과표명，고、중、저제량토별충분균능불동정도강저혈청담고순、감유삼지、저밀도지단백함량화간장지수，병승고혈청고밀도지단백적함량，단여모형조비，고、중제량조차이현저（P<0.05），저제량조차이불현저；여공백조비，고、중제량조차이불현저，저제량조TC、TG함량화간장지수차이현저（P<0.05）。결과표명，토별충분대고지혈증가토구유조절화강저혈지수평적작용，최괄의제량선용중제량0.30 g·kg-1。
The effect of Eupolyphaga powder on liver index and blood lipid of hyperlipemia rabbit was studyed by feeding hyperlipemia rabbit on high, medium and low dosage of Eupolyphaga powder. In this experiment, 150 rabbits were selected and randomly divided into five groups:control group, model group, high, medium and low dosage group. The rabbits of three different dosage groups were feed on a dosage of 0.45, 0.30 and 0.15 g·kg-1 respectively. Weighing on empty stomach, heart blood col ection, detection of serum cholesterol, triglyceride, low density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) content, slaughtering and weighing after the liver, liver index calculation were performed when molding ends and the 10th, 20th, 30th day after dosing. The results showed that al three dosage of Eupolyphaga powder could reduce serum cholesterol, triglyceride, low density lipoprotein levels and liver index in different degrees, and increase the content of serum high density lipoprotein cholesterol. However, high and medium dosage group were significantly different from model group (P<0.05), and low dosage group was not significant;high and medium dosage group were significantly different from control group, TC, TG content and liver index in the low dosage group was significantly different (P<0.05). The results showed that Eupoly-phaga powder could regulate and reduce blood lipid level of rabbit with hyperlipemia and the suitable dosage was 0.30 g·kg-1.