CAJ | 학술논문

以小鼠为材料，以尿素包合法制得的黄粉虫油脂多不饱和脂肪酸为受试剂，研究了黄粉虫幼虫多不饱和脂肪酸对小鼠体质量、血清总胆固醇（ TC）、甘油三脂（ TG）、高密度脂蛋白胆固醇（ HDL-C）及低密度脂蛋白胆固醇（ LDL-C）含量的影响；同时，研究了黄粉虫多不饱和脂肪酸对小鼠肝脏总脂酶（ LA）活性、肝脂酶（ HL）活性、脂蛋白脂肪酶（LPL）活性、肝脏组织中丙二醛（MDA）及脂褐质（LF）含量的影响。结果表明：与高脂对照组相比，黄粉虫多不饱和脂肪酸能显著降低小鼠体质量、血清中TC、TG、LDL-C水平及肝脏中MDA质量摩尔浓度（P＜0．01）；而血清HDL-C（P＜0．01）水平及肝脏中HL（P＜0．01）、LPL（P＜0．05）、LA（P＜0．01）水平有显著性提高；LF质量分数无显著变化。说明黄粉虫多不饱和脂肪酸对小鼠脂代谢具有积极的调节作用。
이소서위재료，이뇨소포합법제득적황분충유지다불포화지방산위수시제，연구료황분충유충다불포화지방산대소서체질량、혈청총담고순（ TC）、감유삼지（ TG）、고밀도지단백담고순（ HDL-C）급저밀도지단백담고순（ LDL-C）함량적영향；동시，연구료황분충다불포화지방산대소서간장총지매（ LA）활성、간지매（ HL）활성、지단백지방매（LPL）활성、간장조직중병이철（MDA）급지갈질（LF）함량적영향。결과표명：여고지대조조상비，황분충다불포화지방산능현저강저소서체질량、혈청중TC、TG、LDL-C수평급간장중MDA질량마이농도（P＜0．01）；이혈청HDL-C（P＜0．01）수평급간장중HL（P＜0．01）、LPL（P＜0．05）、LA（P＜0．01）수평유현저성제고；LF질량분수무현저변화。설명황분충다불포화지방산대소서지대사구유적겁적조절작용。
To improve the available use of resource insects, with Tenebrio molitor as material, we studied in functional test of Tenebrio molitor larva polyunsaturated fatty acid.Polyunsaturated fatty acid was concentrated from Tenebrio molitor oil by urea inclusion method.Fifty mice were divided into five groups randomly.Except blank control group, the other four groups were fed with high fat diet.Blank control and obesity control groups were fed with physiological salt water, and the doses groups were fed with different doses polyunsaturated fatty acid.Body weights were weighed every week.After four weeks, the mice were killed, the blood andhepar were collected.With mice, the experiment was conducted to study the effect of Tenebrio molitor polyunsaturated fatty acid on the mouse body mass, the serum total triglycerides ( TC) , total cho-lesterol (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C), as well as hepatic total lipase ( LA) , hepatic lipase ( HL) , lipoprotein lipase ( LPL) , malondialdehyde ( MDA) and hepar lipo-fuscin (LF).Compared with obesity control group, the body weight, TC, TG, LDL-C and MDA levels were reduced sig-nificantly (P<0.01) by T.molitor polyunsaturated fatty acid.HDL-C (P<0.01), HL (P<0.01), LPL (P<0.05) and LA (P<0.01) levels were enhanced significantly.There was no significant change in LF level. Therefore, T.molitor pol-yunsaturated fatty acid can enhance the mouse lipid metabolism .