CAJ | 학술논문

目的：应用氢质子磁共振波谱成像（1 H-MRS ）技术探讨人尿激肽原酶对急性脑梗死患者的疗效及其作用机制。方法将30例急性脑梗死患者随机分为试验组和对照组，对照组给予常规基础治疗和对症支持治疗，试验组在对照组的基础上给予人尿激肽原酶治疗。治疗前、后进行美国国立卫生研究院卒中量表（NIHSS ）、改良 Rankin 量表（mRS ）评分评价临床疗效，并应用1 H-MRS技术测定脑内代谢物NAA、Lac峰值的变化。结果治疗后，两组NIHSS评分和mRS评分均减少，与治疗前比较差异有统计学意义（P #0．05），且试验组与对照组比较差异有统计学意义（P＜0．05）；治疗后，两组NAA峰值升高、Lac峰值减少，与治疗前比较差异有统计学意义（P＜0．05），且试验组与对照组比较差异有统计学意义（P＜0．05）。结论1H-MRS对急性脑梗死早期诊断、疗效与预后的判定有重要价值。
목적：응용경질자자공진파보성상（1 H-MRS ）기술탐토인뇨격태원매대급성뇌경사환자적료효급기작용궤제。방법장30례급성뇌경사환자수궤분위시험조화대조조，대조조급여상규기출치료화대증지지치료，시험조재대조조적기출상급여인뇨격태원매치료。치료전、후진행미국국립위생연구원졸중량표（NIHSS ）、개량 Rankin 량표（mRS ）평분평개림상료효，병응용1 H-MRS기술측정뇌내대사물NAA、Lac봉치적변화。결과치료후，량조NIHSS평분화mRS평분균감소，여치료전비교차이유통계학의의（P #0．05），차시험조여대조조비교차이유통계학의의（P＜0．05）；치료후，량조NAA봉치승고、Lac봉치감소，여치료전비교차이유통계학의의（P＜0．05），차시험조여대조조비교차이유통계학의의（P＜0．05）。결론1H-MRS대급성뇌경사조기진단、료효여예후적판정유중요개치。
Objective To investigate the clinical effects of human urinary kallikrein(HUK)on patients with acute ischemic stroke (AIS)by using 1 H-nuclear magnetic resonance spectroscopy(1 H-MRS)technology and to elucidate the possible mechanism of the agent. Methods Thirty cases of patients with AIS were randomly divided into treatment group and control group,and the control group was given routine treatment and individual therapy,while the treatment group was given HUK treatment based on the control group,and both agents were intravenously infused.The clinical effect was evaluated by the national institutes of health stroke scale (NIHSS )scores and the modified Rankin scale(mRS)scores before and after the treatment.The metabolite alterations of N-acetylaspartate(NAA)peak and Lactate(Lac)peak of the two groups were determined by using 1 H-MRS technology.Results After treatment the NIHSS score and mRS scores of the two groups decreased significantly,compared with pre-treatment,the difference was significant(P<0.05 ),and the treatment group compared with the control group the difference was significant(P<0.05).The two groups included elevated NAA peak and decreased Lac peak after treatment, compared with pre-treatment the difference was significant(P<0.05),and the difference was significant between the treatment group and the control group (P<0.05).Conclusion HUK is an effective treatment for acute cerebral infarction,which can effectively improve the neuro-logical function and reduce cerebral infarction induced by brain injury.