CAJ | 학술논문

目的：建立血管性痴呆气虚血瘀证大鼠模型，并对其进行实证研究。方法对100只大鼠随机分组，模型组68只、假手术组16只、空白对照组16只。大鼠在2-VO术后，使用Morris水迷宫测检模型对大鼠的学习及记忆能力的进行检测，在益气活血化瘀药物干预后30天，进行同样的检测，并用相关的数据以反证动物模型。结果2-VO术后的检测结果是：第4天和第5天的逃避潜伏期显著长于正常组和假手术组；模型组大鼠第4天第5d的游泳路径较对照组和假手术组明显延长。结论血管性痴呆气虚血瘀证大鼠模型是进行血管性痴呆病理机制及其药物疗效评价的理想动物模型，值得在实践中推广运用。
목적：건립혈관성치태기허혈어증대서모형，병대기진행실증연구。방법대100지대서수궤분조，모형조68지、가수술조16지、공백대조조16지。대서재2-VO술후，사용Morris수미궁측검모형대대서적학습급기억능력적진행검측，재익기활혈화어약물간예후30천，진행동양적검측，병용상관적수거이반증동물모형。결과2-VO술후적검측결과시：제4천화제5천적도피잠복기현저장우정상조화가수술조；모형조대서제4천제5d적유영로경교대조조화가수술조명현연장。결론혈관성치태기허혈어증대서모형시진행혈관성치태병리궤제급기약물료효평개적이상동물모형，치득재실천중추엄운용。
Objective Established Vascular dementia rat model of qi-deficiency and blood-stasis syndrome,and its empirical research.Method 100 rats were randomized,68 model group,sham operation group 16,control group 16. 2-VO rats after using the Morris water maze testing for the detection of rat model of learning and memory ability,within 30 days after the qi and blood circulation drug intervention,the same test,and use relevant data to disprove animal models.Results 2-VO after test results are:4th and 5th day of the escape latency was significantly longer than the normal group and sham group;model rats fourth day 5d the swimming path than in the control group and the sham group was significantly prolonged.Conclusion Vascular dementia rat model of qi and blood stasis syndrome is an ideal animal model of vascular dementia pathology and drug efficacy evaluation mechanism,promote the use of worth in practice.