CAJ | 학술논문

目的：探讨健康者血清胃蛋白酶原（PG ）的分布特征并建立其参考值范围。方法选择健康体检者3753例，根据年龄将其分为＜45岁、45～＜60岁、≥60岁组。采用双抗体夹心酶联免疫吸附测定法进行PGⅠ、Ⅱ检测。结果不同年龄段男、女性健康者血清PGⅠ、PGⅡ及PGⅠ/PGⅡ检测结果均呈偏态分布（ P＜0．05）。女性健康者血清 PGⅠ、PGⅠ/PGⅡ水平显著高于男性（ P＜0．01）。相同年龄，男、女性健康者血清PGⅡ水平的差异无统计学意义（ P＞0．05）。相同性别，不同年龄组间PGⅠ水平两两比较，差异无统计学意义（ P＞0．05）；PGⅡ水平随着年龄增大而升高（ P＜0．01）；PGⅠ/PGⅡ水平随着年龄增大而减低（ P＜0．05）。采用百分位数法确定其95％参考值范围，PGⅠ取双侧参考值区间（ P2．5～ P97．5），PGⅡ取单侧上限（≤ P95），PGⅠ/PGⅡ取单侧下限（≥ P5）。结论健康人群血清PGⅠ、PGⅡ、PGⅠ/PGⅡ参考值区间的制定可以为胃病的防治工作提供依据。
목적：탐토건강자혈청위단백매원（PG ）적분포특정병건립기삼고치범위。방법선택건강체검자3753례，근거년령장기분위＜45세、45～＜60세、≥60세조。채용쌍항체협심매련면역흡부측정법진행PGⅠ、Ⅱ검측。결과불동년령단남、녀성건강자혈청PGⅠ、PGⅡ급PGⅠ/PGⅡ검측결과균정편태분포（ P＜0．05）。녀성건강자혈청 PGⅠ、PGⅠ/PGⅡ수평현저고우남성（ P＜0．01）。상동년령，남、녀성건강자혈청PGⅡ수평적차이무통계학의의（ P＞0．05）。상동성별，불동년령조간PGⅠ수평량량비교，차이무통계학의의（ P＞0．05）；PGⅡ수평수착년령증대이승고（ P＜0．01）；PGⅠ/PGⅡ수평수착년령증대이감저（ P＜0．05）。채용백분위수법학정기95％삼고치범위，PGⅠ취쌍측삼고치구간（ P2．5～ P97．5），PGⅡ취단측상한（≤ P95），PGⅠ/PGⅡ취단측하한（≥ P5）。결론건강인군혈청PGⅠ、PGⅡ、PGⅠ/PGⅡ삼고치구간적제정가이위위병적방치공작제공의거。
Objective To investigate the distribution characteristics of serum pepsinogen (PG) in healthy people and its reference interval establishment .Methods 3 753 healthy people were enrolled and divided into <45-year old ,45- <60-year old and ≥60-year old group according to their ages .Double antibody sandwich enzyme-linked immunosorbent assay was used to detect PG Ⅰ ,Ⅱ . Results Detection results of serum PG Ⅰ ,PGⅡ and PGⅠ /PGⅡ of male and female healthy people in different age group showed a skewed distribution(P<0 .05) .Serum PGⅠ and PGⅠ /PGⅡlevels of females were significantly higher than males(P<0 .01) .In the same age group ,difference of serum PGⅡ levels between males and females was not statistically significant (P>0 .05) .In the same gender ,pairwise comparison of PGⅠlevels was conducted in different age groups ,and the difference showed no statistical sig-nificance(P>0 .05) .PGⅡlevel increased with age increasing (P<0 .01) while PGⅠ /PGⅡlevel increased with age reducing (P<0 .05) .Percentile method was adopted to determine the 95% reference interval ,the bilateral reference intervals (P2 .5 - P97 .5 ) was taken for PGⅠ ,unilateral upper limit(≤ P95 ) for PGⅡ and unilateral limit (≥ P5 ) for PGⅠ /PGⅡ .Conclusion The establishment of serum PG Ⅰ ,PG Ⅱ ,PG Ⅰ /PG Ⅱ reference intervals of healthy people provides a basis for the prevention and treatment for stomach disease .