CAJ | 학술논문

目的：探讨人类白细胞抗原（HLA）-B27对强直性脊柱炎（AS）的诊断价值。方法选择2768例疑诊AS患者作为研究对象，其中600例为确诊AS患者。采用流式细胞术进行血HLA-B27检测。结果2768例疑诊AS的患者中，HLA-B27阳性598例（21．6％），阴性2170例（78．4％）。男、女性患者 HLA-B27阳性率的差异有统计学意义（P＜0．05）；20～＜40岁的AS疑诊患者HLA-B27阳性率显著高于其他年龄段的阳性率（P＜0．05）。600例AS确诊患者中，HLA-B27阳性536例（89．3％）。结论 HLA-B27检测结合临床表现有助于AS的早期诊断。
목적：탐토인류백세포항원（HLA）-B27대강직성척주염（AS）적진단개치。방법선택2768례의진AS환자작위연구대상，기중600례위학진AS환자。채용류식세포술진행혈HLA-B27검측。결과2768례의진AS적환자중，HLA-B27양성598례（21．6％），음성2170례（78．4％）。남、녀성환자 HLA-B27양성솔적차이유통계학의의（P＜0．05）；20～＜40세적AS의진환자HLA-B27양성솔현저고우기타년령단적양성솔（P＜0．05）。600례AS학진환자중，HLA-B27양성536례（89．3％）。결론 HLA-B27검측결합림상표현유조우AS적조기진단。
Objective To investigate the diagnostic value of human leukocyte antigen (HLA )-B27 for ankylosing spondylitis (AS) .Methods 2 768 patients with suspected AS were enrolled ,including 600 patients with confirmed AS .Flow cytometry was performed to detect blood HLA-B27 .Results Among 2 768 patients with suspected AS ,598(21 .6% ) patients were found HLA-B27 positive and 2 170(78 .4% ) patients negative .Difference of HLA-B27 positive rates between male and female patients was sta-tistically significant(P< 0 .05) .HLA-B27 positive rate of patients aged 20 - < 40 years was significantly higher than the others (P<0 .05) .Among 600 patients with confirmed AS ,536 cases(89 .3% ) was found HLA-B27 positive .Conclusion HLA-B27 de-tection combined with clinical manifestations contribute to early diagnosis of AS .