国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
10期
1282-1284
,共3页
李东杰%张亚梅%吴涛%朴文花
李東傑%張亞梅%吳濤%樸文花
리동걸%장아매%오도%박문화
卵巢肿瘤%早期诊断%附睾分泌蛋白质类%可溶性间皮素相关肽%糖链抗原125
卵巢腫瘤%早期診斷%附睪分泌蛋白質類%可溶性間皮素相關肽%糖鏈抗原125
란소종류%조기진단%부고분비단백질류%가용성간피소상관태%당련항원125
ovarian neoplasms%early diagnosis%epididymal secretory proteins%soluble mesothelin related peptides%car-bohydrate antigen 125
目的：评估糖链抗原125（CA125）、人附睾蛋白4（HE4）、可溶性间皮素相关肽（SMRP）联合检测在卵巢癌早期诊断中的价值及卵巢癌的高风险因素。方法选择43例卵巢恶性肿瘤患者作为恶性组，54例卵巢良性肿瘤患者作为良性组，45例健康妇女作为对照组。采用Roche Cobas 6000全自动电化学发光免疫分析仪，酶联免疫吸附测定（ELISA ）检测血清CA125、HE4、SMRP水平，并对卵巢癌高风险因素进行Logistic回归分析。结果恶性组患者血清CA125、HE4及SMRP水平显著高于良性组及对照组（P＜0．01）。CA125、HE4及SMRP单独检测诊断卵巢恶性肿瘤的敏感性分别为73．3％、82．8％及70．8％，特异性分别为79．1％、87．4％及83．3％。CA125与HE4、SMRP三者联合诊断卵巢恶性肿瘤的敏感性为90．2％，特异性为79．3％。Logis-tic回归分析发现，初潮年龄小于13岁、月经周期小于30 d、月经不规则为卵巢恶性肿瘤高危因素，其比值比（OR）分别为2．11[95％可信区间（CI）：1．09～4．10]、1．91（95％ CI：1．21～3．10）、1．57（95％ CI：0．83～2．94）。结论 CA125联合 HE4或SMRP检测可明显提高诊断卵巢癌的敏感性。
目的：評估糖鏈抗原125（CA125）、人附睪蛋白4（HE4）、可溶性間皮素相關肽（SMRP）聯閤檢測在卵巢癌早期診斷中的價值及卵巢癌的高風險因素。方法選擇43例卵巢噁性腫瘤患者作為噁性組，54例卵巢良性腫瘤患者作為良性組，45例健康婦女作為對照組。採用Roche Cobas 6000全自動電化學髮光免疫分析儀，酶聯免疫吸附測定（ELISA ）檢測血清CA125、HE4、SMRP水平，併對卵巢癌高風險因素進行Logistic迴歸分析。結果噁性組患者血清CA125、HE4及SMRP水平顯著高于良性組及對照組（P＜0．01）。CA125、HE4及SMRP單獨檢測診斷卵巢噁性腫瘤的敏感性分彆為73．3％、82．8％及70．8％，特異性分彆為79．1％、87．4％及83．3％。CA125與HE4、SMRP三者聯閤診斷卵巢噁性腫瘤的敏感性為90．2％，特異性為79．3％。Logis-tic迴歸分析髮現，初潮年齡小于13歲、月經週期小于30 d、月經不規則為卵巢噁性腫瘤高危因素，其比值比（OR）分彆為2．11[95％可信區間（CI）：1．09～4．10]、1．91（95％ CI：1．21～3．10）、1．57（95％ CI：0．83～2．94）。結論 CA125聯閤 HE4或SMRP檢測可明顯提高診斷卵巢癌的敏感性。
목적：평고당련항원125（CA125）、인부고단백4（HE4）、가용성간피소상관태（SMRP）연합검측재란소암조기진단중적개치급란소암적고풍험인소。방법선택43례란소악성종류환자작위악성조，54례란소량성종류환자작위량성조，45례건강부녀작위대조조。채용Roche Cobas 6000전자동전화학발광면역분석의，매련면역흡부측정（ELISA ）검측혈청CA125、HE4、SMRP수평，병대란소암고풍험인소진행Logistic회귀분석。결과악성조환자혈청CA125、HE4급SMRP수평현저고우량성조급대조조（P＜0．01）。CA125、HE4급SMRP단독검측진단란소악성종류적민감성분별위73．3％、82．8％급70．8％，특이성분별위79．1％、87．4％급83．3％。CA125여HE4、SMRP삼자연합진단란소악성종류적민감성위90．2％，특이성위79．3％。Logis-tic회귀분석발현，초조년령소우13세、월경주기소우30 d、월경불규칙위란소악성종류고위인소，기비치비（OR）분별위2．11[95％가신구간（CI）：1．09～4．10]、1．91（95％ CI：1．21～3．10）、1．57（95％ CI：0．83～2．94）。결론 CA125연합 HE4혹SMRP검측가명현제고진단란소암적민감성。
Objective To evaluate the values of combined detection of carbohydrate antigen 125(CA125) ,human epididymis gene protein 4(HE4) ,soluble mesothelin related peptides(SMRP) in early diagnosis for ovarian cancer and the high-risk factors of ovari-an cancer .Methods 43 patients with malignant ovarian cancer were served as the malignant group ,54 patients with benign ovarian tumors as the benign group ,45 healthy women as the control group .Roche Cobas 6000 Automatic Electrochemiluminescence Immu-noassay Analyzer and enzyme-linked immunosorbent assay (ELISA) were adopted to detect serum CA125 ,HE4 ,SMRP levels . High-risk factors of ovarian cancer was subject to Logistic regression analysis .Results Serum levels of CA125 ,HE4 and SMRP of patients in malignant group were significantly higher than those in the benign group and the control group (P<0 .01) .The sensitivi-ties of CA125 ,HE4 and SMRP detection alone for ovarian cancer diagnosis were 73 .3% ,82 .8% and 70 .8% ,respectively ,while their specificities were 79 .1% ,87 .4% and 83 .3% ,respectively .The sensitivity and specificity of joint detection of CA 125 ,HE4 , SMRP for ovarian cancer diagnosis were 90 .2% and 79 .3% ,respectively .Logistic regression analysis showed that age at menarche younger than 13 years ,menstrual cycle less than 30 d and irregular menstruation were the high-risk factors of ovarian cancer ,with their odds ratio(OR) of 2 .11[95% confidence interval(CI):1 .09-4 .10 ,1 .91(95% CI:1 .21-3 .10) and 1 .57(95% CI:0 .83-2 .94) .Conclusion CA125 detection combined with HE4 or SMRP can markedly improve the diagnostic sensitivity for ovarian cancer .
