CAJ | 학술논문

目的：探讨急性胰腺炎（A P ）患者凝血功能、血小板相关参数的改变及其临床意义。方法将36例A P患者作为A P组，38例健康者作为对照组，检测对照组健康者及A P组患者入院时、缓解期血清淀粉酶、脂肪酶、白细胞、中性粒细胞、淋巴细胞、血小板、平均血小板体积（M PV ）、血小板分布宽度（PDW ）、凝血酶原时间（PT ）、凝血酶时间（T T ）、活化部分凝血活酶时间（APTT）、凝血酶原活动度（PTA）、国际标准化比值（INR）、纤维蛋白原（FIB）及D-二聚体（D-D）水平。结果 AP组患者血清淀粉酶、脂肪酶、TT、INR、FIB、D-D水平明显高于对照组（P＜0．01），而其PT、PTA水平明显低于对照组（P＜0．01）。AP患者入院时白细胞、中性粒细胞、淋巴细胞及MPV与缓解期的差异有统计学意义（P＜0．01）。结论对AP患者凝血功能、血小板相关参数改变的检测有助于患者病情及预后的评估。
목적：탐토급성이선염（A P ）환자응혈공능、혈소판상관삼수적개변급기림상의의。방법장36례A P환자작위A P조，38례건강자작위대조조，검측대조조건강자급A P조환자입원시、완해기혈청정분매、지방매、백세포、중성립세포、림파세포、혈소판、평균혈소판체적（M PV ）、혈소판분포관도（PDW ）、응혈매원시간（PT ）、응혈매시간（T T ）、활화부분응혈활매시간（APTT）、응혈매원활동도（PTA）、국제표준화비치（INR）、섬유단백원（FIB）급D-이취체（D-D）수평。결과 AP조환자혈청정분매、지방매、TT、INR、FIB、D-D수평명현고우대조조（P＜0．01），이기PT、PTA수평명현저우대조조（P＜0．01）。AP환자입원시백세포、중성립세포、림파세포급MPV여완해기적차이유통계학의의（P＜0．01）。결론대AP환자응혈공능、혈소판상관삼수개변적검측유조우환자병정급예후적평고。
Objective To study the changes of coagulation function and platelet-related parameters of patients with acute pancre-atitis(AP) and their clinical significance .Methods 36 patients with AP were served as the AP group ,38 healthy people ,the control group .Healthy people in the control group and patients in the AP group at the time of admission and remission were subjected to detection of serum amylase ,lipase ,leukocytes ,neutrophils ,lymphocytes ,platelets ,mean platelet volume(MPV) ,platelet distribution width(PDW),prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT),prothrombin activity (PTA) ,international normalized ratio (INR) ,fibrinogen(FIB) and D-dimer(D-D) levels .Results Levels of serum amylase ,lipase , TT ,INR ,FIB ,and D-D of patients in AP group were significantly higher than those in the control group(P<0 .01) ,while their PT , PTA levels were significantly lower than those in the control group (P<0 .01) .Differences of leukocytes ,neutrophils ,lymphocytes and MPV of AP patients between at the time of admission and remission were statistically significant (P<0 .01) .Conclusion De-tections of coagulation function and platelet-related parameters changes of AP patients contribute to evaluation of the patients′con-dition and prognosis .