CAJ | 학술논문

目的：探讨巴曲酶对突发性耳聋患者凝血及纤维蛋白溶解功能的影响。方法选择突发性耳聋患者87例，在巴曲酶治疗前及治疗3、6 d后检测患者凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原（Fib）、D-二聚体及纤维蛋白（原）降解产物（FDP）。结果与治疗前比较，经巴曲霉治疗后，患者 PT、TT 延长（P＜0．05），Fib降低（P＜0．01），FDP升高（P＜0．01），而APTT、D-二聚体的差异无统计学意义（P＞0．05）。结论 PT、TT、Fib、FDP可用于巴曲酶治疗突发性耳聋患者凝血及纤维蛋白溶解功能的监测。
목적：탐토파곡매대돌발성이롱환자응혈급섬유단백용해공능적영향。방법선택돌발성이롱환자87례，재파곡매치료전급치료3、6 d후검측환자응혈매원시간（PT）、활화부분응혈활매시간（APTT）、응혈매시간（TT）、섬유단백원（Fib）、D-이취체급섬유단백（원）강해산물（FDP）。결과여치료전비교，경파곡매치료후，환자 PT、TT 연장（P＜0．05），Fib강저（P＜0．01），FDP승고（P＜0．01），이APTT、D-이취체적차이무통계학의의（P＞0．05）。결론 PT、TT、Fib、FDP가용우파곡매치료돌발성이롱환자응혈급섬유단백용해공능적감측。
Objective To investigate the effects of batroxobin on blood coagulation and fibrinolytic function of patients with sud-den deafness .Methods 87 patients with sudden deafness were enrolled .Their prothrombin time(PT ) ,activated partial thrombo-plastin time(APTT) ,thrombin time(TT) ,fibrinogen(Fib) ,D-dimer and fibrin/fibrinogen degradation products(FDP) were detec-ted before batroxobin treatment and 3 ,6 days after treatment .Results Compared with pre-treatment ,patients after treatment expe-rienced prolonged PT and TT (P<0 .05) ,decreased Fib(P<0 .01) ,increased FDP (P<0 .01) ,and the difference of APTT ,D-di-mer between treatment before and after showed no statistically significant (P>0 .05) .Conclusion PT ,TT ,Fib ,FDP can be applied to monitor the coagulation and fibrinolytic function of patients with sudden deafness treated with batroxobin .