CAJ | 학술논문

目的：对比不同剂量非布司他与别嘌呤醇对高尿酸血症伴痛风患者血清可溶性细胞间黏附分子1（sICAM-1）水平的影响，探讨其抗炎作用。方法选取2010年6-10月在南京医科大学附属医院门诊就诊的高尿酸血症伴痛风（缓解期）患者60例，采用随机数字表法将患者分为A组、B组、C组，每组20例。A组患者服用40 mg非布司他片，1片/次，1次/d；B组患者服用80 mg非布司他片，1片/次，1次/d；C组患者服用300 mg别嘌呤醇片，1片/次，3次/d。3组患者均连续治疗24周。检测3组患者治疗前及治疗12周、治疗24周时血清sICAM-1、尿酸水平。结果组内比较，3组患者治疗前及治疗12周、治疗24周时血清sICAM-1、尿酸水平间差异均有统计学意义（ P﹤0.05）；组间比较，3组患者治疗前及治疗12周、治疗24周时血清sICAM-1、尿酸水平间差异均无统计学意义（ P﹥0.05）。Pearson相关分析结果显示，血清sICAM-1水平与尿酸水平呈正相关（r＝0.248，P＝0.007）。结论40mg非布司他、80 mg非布司他与别嘌呤醇均可降低高尿酸血症伴痛风患者血清sICAM-1、尿酸水平，可能对改善炎症状态、保护血管内皮细胞功能起着积极作用。
목적：대비불동제량비포사타여별표령순대고뇨산혈증반통풍환자혈청가용성세포간점부분자1（sICAM-1）수평적영향，탐토기항염작용。방법선취2010년6-10월재남경의과대학부속의원문진취진적고뇨산혈증반통풍（완해기）환자60례，채용수궤수자표법장환자분위A조、B조、C조，매조20례。A조환자복용40 mg비포사타편，1편/차，1차/d；B조환자복용80 mg비포사타편，1편/차，1차/d；C조환자복용300 mg별표령순편，1편/차，3차/d。3조환자균련속치료24주。검측3조환자치료전급치료12주、치료24주시혈청sICAM-1、뇨산수평。결과조내비교，3조환자치료전급치료12주、치료24주시혈청sICAM-1、뇨산수평간차이균유통계학의의（ P﹤0.05）；조간비교，3조환자치료전급치료12주、치료24주시혈청sICAM-1、뇨산수평간차이균무통계학의의（ P﹥0.05）。Pearson상관분석결과현시，혈청sICAM-1수평여뇨산수평정정상관（r＝0.248，P＝0.007）。결론40mg비포사타、80 mg비포사타여별표령순균가강저고뇨산혈증반통풍환자혈청sICAM-1、뇨산수평，가능대개선염증상태、보호혈관내피세포공능기착적겁작용。
Objective To explore the influence of febuxostat and allopurinol on soluble intercellular adhesion molecule 1(sICAM -1)in patients with hyperuricemia complicated by gout. Methods Sixty patients with hyperuricemia and gout admitted to Nanjing Hospital from June to October 2010 were randomly divided into group A,B,C,20 in each. Group A administered 40 mg febuxostat,1 piece/ time,1 time/ d;group B given 80 mg febuxostat,1 piece/ time,1 time/ d;group C had 300 mg allopurinol tablets,1 piece/ time,3 times/ d. The courses lasted 24 weeks. The serum sICSM - 1,uric acid( UA) levels were determined before treatment,in weeks 12,24 after treatment. Results In intra - class comparison,there were significant differences in sICAM -1,UA levels in 3 groups before treatment,in weeks 12,24(P ﹤0. 05);in group comparison, there was no significant difference in 3 groups(P ﹥0. 05). Pearson correlation analysis showed that serum sICAM -1 was positively correlated with UA(r =0. 248,P = 0. 007). Conclusion 40 mg,80 mg febuxostat and allopurinol can reduce serum sICAM -1,UA levels in patients with hyperuricemia complicated by gout,which may play an active role in improving inflammation ,protecting vascular endothelial cell function.