中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2014年
15期
1715-1718
,共4页
糖尿病视网膜病变%脂蛋白(A)%清蛋白尿%危险因素
糖尿病視網膜病變%脂蛋白(A)%清蛋白尿%危險因素
당뇨병시망막병변%지단백(A)%청단백뇨%위험인소
Diabetic retinopathy%Lipoprotein(a)%Albuminuria%Risk factors
目的：探讨与糖尿病视网膜病变（DR）发生相关的生化指标，以期寻找出 DR 的高危因素。方法选取2012年4-7月在新疆医科大学第一附属医院就诊的行荧光素眼底血管造影（FFA）或眼底照相检查的2型糖尿病患者142例，将其分为3组：单纯糖尿病组（NDR 组，55例）、非增殖期糖尿病视网膜病变组（NPDR 组，67例）和增殖期糖尿病视网膜病变组（PDR 组，20例）。采血测定相关生化指标，同期留置24 h 尿测定尿微量清蛋白。结果（1）NDR 组、NPDR组、PDR 组糖尿病病程、脂蛋白（ a）〔 Lp（ a）〕、尿微量清蛋白水平均依次增加（ P <0.05）；NPDR 组、PDR 组高血压病程均长于 NDR 组（ P 值分别为0.011和0.007）；PDR 组肌酐水平高于 NDR 组（ P =0.005）；PDR 组尿素氮水平高于 NDR 组、NPDR 组（P 值分别为0.001和0.010）。（2）多因素 Logistic 回归分析显示：糖尿病病程、Lp（a）、尿微量清蛋白与 DR 的发生存在回归关系（ P <0.05）。结论除了糖尿病病程长外，血清Lp（a）及尿微量清蛋白水平高均是 DR 发病的独立危险因素，故检测二者可以预测 DR 的发生及尽早制定临床处理方案。
目的：探討與糖尿病視網膜病變（DR）髮生相關的生化指標，以期尋找齣 DR 的高危因素。方法選取2012年4-7月在新疆醫科大學第一附屬醫院就診的行熒光素眼底血管造影（FFA）或眼底照相檢查的2型糖尿病患者142例，將其分為3組：單純糖尿病組（NDR 組，55例）、非增殖期糖尿病視網膜病變組（NPDR 組，67例）和增殖期糖尿病視網膜病變組（PDR 組，20例）。採血測定相關生化指標，同期留置24 h 尿測定尿微量清蛋白。結果（1）NDR 組、NPDR組、PDR 組糖尿病病程、脂蛋白（ a）〔 Lp（ a）〕、尿微量清蛋白水平均依次增加（ P <0.05）；NPDR 組、PDR 組高血壓病程均長于 NDR 組（ P 值分彆為0.011和0.007）；PDR 組肌酐水平高于 NDR 組（ P =0.005）；PDR 組尿素氮水平高于 NDR 組、NPDR 組（P 值分彆為0.001和0.010）。（2）多因素 Logistic 迴歸分析顯示：糖尿病病程、Lp（a）、尿微量清蛋白與 DR 的髮生存在迴歸關繫（ P <0.05）。結論除瞭糖尿病病程長外，血清Lp（a）及尿微量清蛋白水平高均是 DR 髮病的獨立危險因素，故檢測二者可以預測 DR 的髮生及儘早製定臨床處理方案。
목적：탐토여당뇨병시망막병변（DR）발생상관적생화지표，이기심조출 DR 적고위인소。방법선취2012년4-7월재신강의과대학제일부속의원취진적행형광소안저혈관조영（FFA）혹안저조상검사적2형당뇨병환자142례，장기분위3조：단순당뇨병조（NDR 조，55례）、비증식기당뇨병시망막병변조（NPDR 조，67례）화증식기당뇨병시망막병변조（PDR 조，20례）。채혈측정상관생화지표，동기류치24 h 뇨측정뇨미량청단백。결과（1）NDR 조、NPDR조、PDR 조당뇨병병정、지단백（ a）〔 Lp（ a）〕、뇨미량청단백수평균의차증가（ P <0.05）；NPDR 조、PDR 조고혈압병정균장우 NDR 조（ P 치분별위0.011화0.007）；PDR 조기항수평고우 NDR 조（ P =0.005）；PDR 조뇨소담수평고우 NDR 조、NPDR 조（P 치분별위0.001화0.010）。（2）다인소 Logistic 회귀분석현시：당뇨병병정、Lp（a）、뇨미량청단백여 DR 적발생존재회귀관계（ P <0.05）。결론제료당뇨병병정장외，혈청Lp（a）급뇨미량청단백수평고균시 DR 발병적독립위험인소，고검측이자가이예측 DR 적발생급진조제정림상처리방안。
Objective To investigate the biochemical indicators which related to occurrence of diabetic retinopathy, thus risk factors for diabetic retinopathy may be found. Methods A total of 142 type 2 diabetes patients who underwent the exam-ination of fundus fluorescein angiography(FFA)or fundus photography check in the First Affiliated Hospital of Xinjiang Medical University from April to July 2012,were divided into 3 groups:the simple diabetes group(NDR group,55 cases),non - pro-liferative diabetic retinopathy group( NPDR group,67 cases),proliferative diabetic retinopathy group( PDR group,20 ca-ses). Blood biochemical indicators were determined,at the same time,microalbuminuria level was determined through 24 -hour urine retention. Results The course of diabetes,levels of lipoprotein(a)〔Lp(a)〕and microalbuminuria increased in an order from NDR group,NPDR group,PDR group(P < 0. 05). The course of hypertension in NPDR group and PDR group was significantly longer than that in NDR group(P = 0. 011 and 0. 007,respectively). The creatinine level in PDR group was significantly higher than that in NDR group(P = 0. 005). The urea nitrogen level in PDR group was significantly higher than those in NDR group and NPDR group(P = 0. 001 and 0. 010,respectively). Logistic regression analysis showed that there were remarkable regression relationships between diabetic retinopathy(DR)and course of diabetes,levels of Lp(a)and microalbu-minuria(P < 0. 05). Conclusion The long course of diabetes,high levels of Lp(a)and microalbuminuria are independent risk factors for the occurrence of DR. Determination of Lp(a)and microalbuminuria can predict the occurrence of DR to some ex-tent,and may contribute to making clinical treatment plan early.
