CAJ | 학술논문

目的探讨牛磺酸对高同型半胱氨酸脑梗死患者动脉粥样硬化的治疗作用. 方法选择自2006年9月至2006年12月哈尔滨医科大学附属第一医院神经内科住院的40例高同型半胱氨酸脑梗死患者,按随机数字表法分为牛磺酸治疗组和叶酸、维生素治疗组,相应的药物治疗6个月.治疗前后分别检查颈动脉彩超,观察颈动脉内膜中层厚度(IMT)和斑块变化情况,采血分离血清,采用高压液相色谱分析仪及相应试剂盒测定血浆同型半胱氨酸水平. 结果经治疗6个月后,叶酸、维生素组颈动脉IMT平均厚度减小0.372 mm,牛磺酸治疗组减小0.551 mm,两组在治疗前后颈动脉IMT比较差异均有统计学意义(P<0.05),且牛磺酸治疗组对颈动脉IMT的控制要优于叶酸、维生素治疗组,差异有统计学意义(P<0.05).牛磺酸治疗组治疗前后血浆同型半胱氨酸水平[(29.832±7.750)μmol/Lvs(19.316±2.240)μmol/L]比较差异有统计学意义(P<0.05). 结论牛磺酸对高同型半胱氨酸脑梗死患者动脉粥样硬化的治疗有效且优于叶酸、维生素,并对血浆同型半胱氨酸水平有控制作用.
목적 탐토우광산대고동형반광안산뇌경사환자동맥죽양경화적치료작용. 방법선택자2006년9월지2006년12월합이빈의과대학부속제일의원신경내과주원적40례고동형반광안산뇌경사환자,안수궤수자표법분위우광산치료조화협산、유생소치료조,상응적약물치료6개월.치료전후분별검사경동맥채초,관찰경동맥내막중층후도(IMT)화반괴변화정황,채혈분리혈청,채용고압액상색보분석의급상응시제합측정혈장동형반광안산수평. 결과경치료6개월후,협산、유생소조경동맥IMT평균후도감소0.372 mm,우광산치료조감소0.551 mm,량조재치료전후경동맥IMT비교차이균유통계학의의(P<0.05),차우광산치료조대경동맥IMT적공제요우우협산、유생소치료조,차이유통계학의의(P<0.05).우광산치료조치료전후혈장동형반광안산수평[(29.832±7.750)μmol/Lvs(19.316±2.240)μmol/L]비교차이유통계학의의(P<0.05). 결론우광산대고동형반광안산뇌경사환자동맥죽양경화적치료유효차우우협산、유생소,병대혈장동형반광안산수평유공제작용.
Objective To investigate the therapeutic effect of taurine on atherosclerosis in patients with hyperhomocysteinemia (Hhcy)-induced cerebral infarction (CI). Methods Forty patients with CI induced by Hhcy were randomizod into two equal groups to receive taurine injections or folacin plus vitamin B12 treatment for 6 months. Color Doppler ultrasound was performed to examine the intima-media thickness (IMT) and the plaques in the carotid artery before and after the treatment. Blood samples were obtained from the patients to determine the changes in plasma homocysteic acid (Hcy) level using high-pressure liquid chromatography. Results Both taurine injections and folacin plus vitamin BI2 treatment for 6 months resulted in a significant reduction in the IMT of the carotid artery (P<0.05), but taurine caused a significantly greater reduction (0.551 mm vs 0.372 mm, P<0.05). Taurine also showed a better effect than folacin plus vitamin B12 in decreasing the number of atherosclcrotic plaques (P<0.05). Taurine treatment significantly decreased the plasma Hcy level as compared with the level before treatment (19.316±2.240 μmol/L v, 29.832±7.750 μmol/L, P<0.05). Conclusions Taurine has better therapeutic effect than folacin plus vitamine B12 oil atherosclerosis and helps control plasma Hcy level in patients with Hhcy-induced CI.