CAJ | 학술논문

背景：用于心血管医疗的生物材料在血液接触性条件下必须具有抗血栓性、对抗生物降解性与抗感染性。 　　目的：研制用于心血管组织工程的新型植(介)入型聚合物材料(表面)，从聚合物生物材料的表面构建与生物反应行为方面考察各种相应改性表面的生物相容性、血液相容性和细胞相容性。 　　方法：检索1984至2013年PubMed数据库及万方数据库，英文检索词为“Biocompatibility, Blood compatibility, Biomedical Materials, Biomedical polymer materials”，中文检索词为“生物相容性材料；血液相容性材料；生物医用材料；医用高分子材料”。 　　结果与结论：通过对蛋白质吸附、细胞黏附中的生物识别、凝血与纤溶过程中的酶催化作用“瀑布模型”，以及生物材料表面构建与蛋白质表面吸附行为4个方面的归纳分析，研制用于心血管组织工程的新型植(介)入型聚合物材料(表面)关键在于对聚合物生物材料生物功能性表面的构建，以及对其相应生物相容性与内皮细胞相容性的研究。通过对聚合物生物材料种类与应用及其心血管医疗器件和可植入性软组织替代物的深入研究可以发现，表面与本体的差别将体现在从表面向本体延伸的很多层分子上，而两种主要因素决定了其包括本体/表面差异及表面相分离在内的本体/表面行为，即表面能和分子运动性。如果考虑到对本体-表面组成差异的理解，还必须追加附加决定因素，即各组分的结晶行为。
배경：용우심혈관의료적생물재료재혈액접촉성조건하필수구유항혈전성、대항생물강해성여항감염성。 　　목적：연제용우심혈관조직공정적신형식(개)입형취합물재료(표면)，종취합물생물재료적표면구건여생물반응행위방면고찰각충상응개성표면적생물상용성、혈액상용성화세포상용성。 　　방법：검색1984지2013년PubMed수거고급만방수거고，영문검색사위“Biocompatibility, Blood compatibility, Biomedical Materials, Biomedical polymer materials”，중문검색사위“생물상용성재료；혈액상용성재료；생물의용재료；의용고분자재료”。 　　결과여결론：통과대단백질흡부、세포점부중적생물식별、응혈여섬용과정중적매최화작용“폭포모형”，이급생물재료표면구건여단백질표면흡부행위4개방면적귀납분석，연제용우심혈관조직공정적신형식(개)입형취합물재료(표면)관건재우대취합물생물재료생물공능성표면적구건，이급대기상응생물상용성여내피세포상용성적연구。통과대취합물생물재료충류여응용급기심혈관의료기건화가식입성연조직체대물적심입연구가이발현，표면여본체적차별장체현재종표면향본체연신적흔다층분자상，이량충주요인소결정료기포괄본체/표면차이급표면상분리재내적본체/표면행위，즉표면능화분자운동성。여과고필도대본체-표면조성차이적리해，환필수추가부가결정인소，즉각조분적결정행위。
BACKGROUND:Cardiovascular biomaterials applied under the blood-contact conditions must have anti-thrombotic, anti-biodegradable and anti-infective properties. OBJECTIVE:To develop novel polymer materials for implantation and intervention in cardiovascular tissue engineering and then to explore the biological, blood and cellcompatibilities of corresponding surface-modified polymer biomaterials based on surface construction and biological response. METHODS:We retrieved PubMed and WanFang databases for relevant articles publishing from 1984 to 2013. The key words were“biocompatibility, blood compatibility, biomedical materials, biomedical polymer materials”in English and Chinese, respectively. RESULTS AND CONCLUSION:Here, we analyze the fol owing four aspects:protein adsorption, biometric identification in celladhesion, and the“waterfal model”for enzyme catalysis during blood coagulation and fibrinolysis. Consequently, it is concluded that the functional surface construction of polymer biomaterials and research on corresponding biocompatibility and endothelial cellcompatibility are crucial for developing novel polymer materials for implantation and intervention in cardiovascular tissue engineering. Through in-depth studies of the types and applications of polymer biomaterials, cardiovascular medical devices and implantable soft tissue substitutes, the differences between the surface and the body wil be reflected in the many layers of molecules extending from the surface to the body. Two major factors, surface energy and molecular mobility, determine the body/surface behaviors that include body/surface differences and phase separation. Considering the difference between body/surface composition, an additional determinant is indispensable, that is the crystal ization behavior of each component.