CAJ | 학술논문

缺血后适应的提出源于缺血预适应，脑缺血后适应是指在脑缺血后给予一次或多次反复短暂的动脉闭塞后再灌注以期达到减轻脑组织缺血再灌注损伤的目的。相对于预适应，后适应具有临床治疗的可行性。近年来诸多研究发现其具有明显的脑保护作用，主要对其发现、发展、脑保护作用机制及其临床应用前景进行综述。
결혈후괄응적제출원우결혈예괄응，뇌결혈후괄응시지재뇌결혈후급여일차혹다차반복단잠적동맥폐새후재관주이기체도감경뇌조직결혈재관주손상적목적。상대우예괄응，후괄응구유림상치료적가행성。근년래제다연구발현기구유명현적뇌보호작용，주요대기발현、발전、뇌보호작용궤제급기림상응용전경진행종술。
Ischemic postconditioning is a concept originally defined to contrast with that of ischemic preconditioning. While both preconditioning and postconditioning confer a neuroprotective effect on brain ischemia, preconditioning is a sublethal insult performed in advance of brain ischemia, and postconditioning, which conventionally refers to a series of brief occlusions and reperfusions of the blood vessels, is conducted after ischemia/reperfusion. In recent years, extensive studies show that postconditioning has apparently protective effects. We mainly review the discovery and development, the underlying mechanisms and clinical application of it.