CAJ | 학술논문

目的：观察氟比洛芬酯复合曲马多用于腹部手术患者持续静脉镇痛的有效性及安全性。方法选择ASA分级Ⅰ～Ⅱ级、择期行腹部手术的患者80例，随机分为氟比洛芬酯（F组）和曲马多组（T组），每组40例。F组首量为氟比洛芬酯50mg,镇痛泵内加入氟比洛芬酯200mg、曲马多400mg和托烷司烷5mg并用生理盐水稀释至100ml。T组首量为曲马多100mg,镇痛泵内加入曲马多800mg和托烷司琼5mg并用生理盐水稀释至l00ml。两组均设定相同的PCA参数(2ml/h，按压0.5ml/次，锁定时间15min)。于术后1,3,6,12,24和48h观察并记录患者各时点的VAS评分、统计术后48h内PCIA按压次数及不良反应。结果 F组与T组术后VAS评分及术后48h内按压次数差异无统计学意义，但不良反应存在差异,F组不良反应发生率明显低于T组。结论腹部手术患者持续静脉镇痛应用氟比洛芬酯复合曲马多静脉持续镇痛具有安全、效果确切及不良反应少的优点。
목적：관찰불비락분지복합곡마다용우복부수술환자지속정맥진통적유효성급안전성。방법선택ASA분급Ⅰ～Ⅱ급、택기행복부수술적환자80례，수궤분위불비락분지（F조）화곡마다조（T조），매조40례。F조수량위불비락분지50mg,진통빙내가입불비락분지200mg、곡마다400mg화탁완사완5mg병용생리염수희석지100ml。T조수량위곡마다100mg,진통빙내가입곡마다800mg화탁완사경5mg병용생리염수희석지l00ml。량조균설정상동적PCA삼수(2ml/h，안압0.5ml/차，쇄정시간15min)。우술후1,3,6,12,24화48h관찰병기록환자각시점적VAS평분、통계술후48h내PCIA안압차수급불량반응。결과 F조여T조술후VAS평분급술후48h내안압차수차이무통계학의의，단불량반응존재차이,F조불량반응발생솔명현저우T조。결론복부수술환자지속정맥진통응용불비락분지복합곡마다정맥지속진통구유안전、효과학절급불량반응소적우점。
Objective To observe the efficacy and safety of flurbiprofen axetil combined tramadol ,used for postoperative patient-control ed intravenous analgesia in patients undergoing abdominal surgeries. Methods: EightyⅠ ~ Ⅱlevel of ASA patients undergoing abdominal surgeries were enrol ed in this study. Patients were randomly divided into flurbiprofen group (group F) and tramadol group (group T), 40 cases in each group. The patients in Group F received flurbiprofen axetil 50mg as initial dose, the analgesia pump added with flurbiprofen axetil 200mg, tramadol 400mg and thromboxane 5mg and diluted with saline to 100ml. The initial dose in group T was tramadol 100mg, analgesia pump added with tramadol 800mg and 5mg tropisetron and diluted with saline to l00ml. The two groups were set with the same PCA parameter (2ml/h, per-press 0.5ml, lockout time of15min). After postoperation of 1h,3h,6h,12h,24h and 48h, observed the patients and recorded the VAS scores, and statistics of pressing times and adverse reaction after 48h PCIA. The results of postoperative VAS score and postoperative 48h press times have no significant difference in group F and group T, but there are differences in adverse reactions occurred. The adverse reaction rate in group F was dearly lower than that of group T. Conclusion The usage of combination of Flurbiprofen axetil with Tramadol used in patients undergoing abdominal surgeries in PCIA, can reduce adverse reactions, and get a satisfactory analgesic effect. It is a safe, effective, and convenient analgesic method.