CAJ | 학술논문

目的：观察rhIL-11(重组白细胞介素-11)治疗晚期恶性肿瘤患者行伽马刀放射治疗后血小板减少的疗效。方法：随机将160例晚期癌症分为：A组82例为治疗组(血小板Ⅲ度以上减少病例行rhIL-11治疗)：rhIL-112mg，皮下注射，每日一次，用至 PLT上升至75×109/L或血小板绝对值升高50×109/L；B组78例为对照组，对照组病例不予rhIL-11注射治疗。结果：放疗结束后A、B两组Ⅲ度以上血小板减少发生率基本相同，分别为12.2%、11.5%，（P>0.05）；应用rhIL-11有效率为80%，而对照组血小板自然恢复率为31.6%（P<0.01）。结论：rhIL-11能明显提高晚期恶性肿瘤患者放疗后血小板的数量。
목적：관찰rhIL-11(중조백세포개소-11)치료만기악성종류환자행가마도방사치료후혈소판감소적료효。방법：수궤장160례만기암증분위：A조82례위치료조(혈소판Ⅲ도이상감소병례행rhIL-11치료)：rhIL-112mg，피하주사，매일일차，용지 PLT상승지75×109/L혹혈소판절대치승고50×109/L；B조78례위대조조，대조조병례불여rhIL-11주사치료。결과：방료결속후A、B량조Ⅲ도이상혈소판감소발생솔기본상동，분별위12.2%、11.5%，（P>0.05）；응용rhIL-11유효솔위80%，이대조조혈소판자연회복솔위31.6%（P<0.01）。결론：rhIL-11능명현제고만기악성종류환자방료후혈소판적수량。
Objective:To investigate the efficacy of recombinant human interleukin-11 (rhIL-11) in the treatment of radiotherapy-induced thrombocytopenia in patients diagnosed terminal cancer. Methods:One hundred and sixty diagnosed terminal cancer patients were randomly divided to intra-hypodermic(ih) injection of 50 ug/kg or 1.5 mg/d of rhIL-11 was given when their platelet count was lower than 50×109/L after radiotherapy(treatment group,A) or the same above therapy was given except rhIL-11(control group, B).Results:Upon completion of the radiotherapy, the rates of the thrombocytopenia between the two groups(24.4%and 24.4%) were not significantly different(P>0.05),the effective rate of the treatment group(80%) was higher than the spontaneous recovery rate of control group(31.6%),(P<0.01). Conclusion:Administration of rhlL-11 can significantly increase platelet count in patients.