CAJ | 학술논문

目的：观察慢性左心衰竭患者的血浆内脏脂肪素水平，探讨其与糖脂代谢参数和高敏C反应蛋白（hs- CRP）的关系。方法将50例慢性左心功能不全患者（心力衰竭组）根据超声心动图左心室射血分数（LVEF）分成两亚组：轻度心功能不全亚组（35%＜LVEF≤45%）25例,重度心功能不全亚组（LVEF≤35%）25例；对照组（LVEF＞50%）24例，检测并比较各组hs- CRP、内脏脂肪素、血脂、血糖等指标。结果心力衰竭组内脏脂肪素较对照组降低（5.8±22.1 ng/ml vs 8.5±2.4 ng/ml，P＜0.01）；轻度、重度心功能不全亚组及对照组比较，内脏脂肪素、hs- CRP、血糖、HOMAIR、HDL- C差异均有统计学意义（P＜0.05或0.01）；内脏脂肪素与LVEF呈正相关（r=0.49，P＜0.01），与hs- CRP呈负相关（r=-0.30，P＜0.01）。结论心力衰竭患者的血清内脏脂肪素显著降低，此结果独立于年龄、性别、BMI和代谢参数。
목적：관찰만성좌심쇠갈환자적혈장내장지방소수평，탐토기여당지대사삼수화고민C반응단백（hs- CRP）적관계。방법장50례만성좌심공능불전환자（심력쇠갈조）근거초성심동도좌심실사혈분수（LVEF）분성량아조：경도심공능불전아조（35%＜LVEF≤45%）25례,중도심공능불전아조（LVEF≤35%）25례；대조조（LVEF＞50%）24례，검측병비교각조hs- CRP、내장지방소、혈지、혈당등지표。결과심력쇠갈조내장지방소교대조조강저（5.8±22.1 ng/ml vs 8.5±2.4 ng/ml，P＜0.01）；경도、중도심공능불전아조급대조조비교，내장지방소、hs- CRP、혈당、HOMAIR、HDL- C차이균유통계학의의（P＜0.05혹0.01）；내장지방소여LVEF정정상관（r=0.49，P＜0.01），여hs- CRP정부상관（r=-0.30，P＜0.01）。결론심력쇠갈환자적혈청내장지방소현저강저，차결과독립우년령、성별、BMI화대사삼수。
Objective To determine the serum visfatin levels in patients with chronic heart failure (CHF) and its influencing factors. Methods Fifty patients with chronic heart failure due to left ventricular systolic dysfunction were divided into mild HF group (35%<LVEF≤45%, n=25) and severe HF group (LVEF≤35%, n=25);24 healthy subjects (LVEF>50%) served as control group. Serum visfatin, hsCRP, glucose and lipid metabolism parameters were measured in al subjects. Results Serum visfatin levels in HF groups were significantly lower than those in control group (5.8 ±22.1ng/ml vs 8.5 ±2.4ng/ml, P<0.01). The Kruskal- Wal is test showed significant differences among three groups in serum levels of visfatin, hsCRP, glucose, HOMAIR and HDL- cholesterol(P<0.05 or 0.01). Serum visfatin level was positively correlated with LVEF and negatively correlated with hs- CRP (r=0.49, - 0.30,P<0.01). Conclusion Serum visfatin levels in patients with systolic HF are decreased, which is independent to age, sex, BMI, and metabolic parameters of patients.