浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2014年
6期
475-478
,共4页
徐靓%严静%李莉%龚仕金%蔡国龙%戴海文%虞意华%刘秉宇%余海燕
徐靚%嚴靜%李莉%龔仕金%蔡國龍%戴海文%虞意華%劉秉宇%餘海燕
서정%엄정%리리%공사금%채국룡%대해문%우의화%류병우%여해연
高血压%动脉硬化%心踝指数%B型钠尿肽
高血壓%動脈硬化%心踝指數%B型鈉尿肽
고혈압%동맥경화%심과지수%B형납뇨태
Hypertension%Arterial stiffness%Cardio- ankle vascular index%Btype natriuretic peptide
目的:研究高血压病患者心踝指数(CAVI)与血浆B型钠尿肽(BNP)水平的相关性。方法选择门诊高血压病患者84例,平均年龄(68±7)岁。测定血浆BNP水平、生化指标和CAVI,同时通过超声心动图评估左心室肥厚和心脏舒缩功能。结果BNP与CAVI、年龄、高血压病程相关(r=0.281、0.269、-0.241,均P<0.05),多元线性回归分析显示CAVI为BNP的独立影响因素(β=0.282,P<0.05);另外,CAVI还与年龄、BMI、是否使用β受体阻滞剂相关(r=0.359、-0.234、-0.266,P<0.01或0.05),多元线性回归分析显示年龄为CAVI的独立影响因素(β=0.380,P<0.01)。结论高血压病患者CAVI增高是BNP水平增高的独立危险因素,随着动脉硬化程度的增高,心脏后负荷增大,可能加重心脏损害。
目的:研究高血壓病患者心踝指數(CAVI)與血漿B型鈉尿肽(BNP)水平的相關性。方法選擇門診高血壓病患者84例,平均年齡(68±7)歲。測定血漿BNP水平、生化指標和CAVI,同時通過超聲心動圖評估左心室肥厚和心髒舒縮功能。結果BNP與CAVI、年齡、高血壓病程相關(r=0.281、0.269、-0.241,均P<0.05),多元線性迴歸分析顯示CAVI為BNP的獨立影響因素(β=0.282,P<0.05);另外,CAVI還與年齡、BMI、是否使用β受體阻滯劑相關(r=0.359、-0.234、-0.266,P<0.01或0.05),多元線性迴歸分析顯示年齡為CAVI的獨立影響因素(β=0.380,P<0.01)。結論高血壓病患者CAVI增高是BNP水平增高的獨立危險因素,隨著動脈硬化程度的增高,心髒後負荷增大,可能加重心髒損害。
목적:연구고혈압병환자심과지수(CAVI)여혈장B형납뇨태(BNP)수평적상관성。방법선택문진고혈압병환자84례,평균년령(68±7)세。측정혈장BNP수평、생화지표화CAVI,동시통과초성심동도평고좌심실비후화심장서축공능。결과BNP여CAVI、년령、고혈압병정상관(r=0.281、0.269、-0.241,균P<0.05),다원선성회귀분석현시CAVI위BNP적독립영향인소(β=0.282,P<0.05);령외,CAVI환여년령、BMI、시부사용β수체조체제상관(r=0.359、-0.234、-0.266,P<0.01혹0.05),다원선성회귀분석현시년령위CAVI적독립영향인소(β=0.380,P<0.01)。결론고혈압병환자CAVI증고시BNP수평증고적독립위험인소,수착동맥경화정도적증고,심장후부하증대,가능가중심장손해。
Objective To investigate the relationship between cardio- ankle vascular indexes (CAVIs) and plasma B- type natriuretic peptide (BNP) levels in hypertensive patients. Methods Plasma BNP level, biochemical index, and CAVI were measured in 84 hypertensive patients (68±7)years;and echocardiography was also performed to evaluate left ventricular hypertrophy and function. Results Plasma BNP levels were significantly correlated with CAVI, age and course of disease (r=0.281, 0.269 and - 0.241, P<0.05). Multiple linear regression analysis revealed that CAVI was an independent determinant of BNP (β=0.282, P<0.05). In addition, CAVI was correlated with age, body mass index, and use of βblockers(r=0.359,- 0.234 and - 0.266, P<0.01 or 0.05); and regression analysis revealed that age was an independent determinant of CAVI (β=0.380, P<0.01). Conclusion The present study reveals that increased CAVI is an independent risk factor of elevated plas-ma BNP in hypertensive patients.