CAJ | 학술논문

目的：分析结直肠癌肝转移与血清肿瘤标志物水平的相关性，探讨结直肠癌肝转移的危险因素。方法选取113例结直肠癌肝转移患者，采用化学发光免疫法对其血清标本中癌胚抗原（ CEA）、甲胎蛋白（ AFP）、糖抗原19-9（CA19-9）、糖抗原125（CA125）、糖抗原72-4（CA72-4）、细胞角蛋白21-1（CYFRA21-1）等项目进行检测，并随机抽取同期无肝转移的结直肠癌患者109例作为对照组，Logistic多因素回归分析结直肠癌肝转移的危险因素。结果血清CEA、CA19-9、CA125水平的增高与结直肠癌肝转移具有相关性（ P＜0．05）。 Logistic多因素回归分析显示血清CEA、CA19-9、CA125水平是结直肠癌肝转移的独立相关因素（P＜0．05）。结论血清CEA、CA19-9、CA125水平的升高与结直肠癌肝转移有着一定相关性，是结直肠癌肝转移的危险因素。
목적：분석결직장암간전이여혈청종류표지물수평적상관성，탐토결직장암간전이적위험인소。방법선취113례결직장암간전이환자，채용화학발광면역법대기혈청표본중암배항원（ CEA）、갑태단백（ AFP）、당항원19-9（CA19-9）、당항원125（CA125）、당항원72-4（CA72-4）、세포각단백21-1（CYFRA21-1）등항목진행검측，병수궤추취동기무간전이적결직장암환자109례작위대조조，Logistic다인소회귀분석결직장암간전이적위험인소。결과혈청CEA、CA19-9、CA125수평적증고여결직장암간전이구유상관성（ P＜0．05）。 Logistic다인소회귀분석현시혈청CEA、CA19-9、CA125수평시결직장암간전이적독립상관인소（P＜0．05）。결론혈청CEA、CA19-9、CA125수평적승고여결직장암간전이유착일정상관성，시결직장암간전이적위험인소。
Objective To study the correlation between liver metastases of colorectal cancer and the serum level of tumor markers,and to explore the risk factors for liver metastases of colorectal cancer .Methods CEA,AFP,CA19-9,CA125, CA72-4,CYFRA21-1 and other projects for testing in serum samples of 113 cases of colorectal cancer patients with liver metasta-ses were detected using chemiluminescence immunoassay ,and 109 cases of colorectal cancer patients without liver metastases were selected as the control group .Risk factors for liver metastases of colorectal cancer were studied by logistic regression analysis .Re-sults Increase of serum CEA,CA19-9,CA125 level was correlated with liver metastases of colorectal cancer (P<0.05).Logis-tic regression analysis showed that serum CEA ,CA19-9,CA125 level were independent related factors for liver metastases of colo-rectal cancer (P<0.05).Conclusion Increase of serum CEA,CA19-9,CA125 level has a certain relevance with liver metasta-ses of colorectal cancer ,and it is risk factors for liver metastases of colorectal cancer .