CAJ | 학술논문

目的：初步探讨人附睾蛋白4在子宫富于细胞型平滑肌瘤中的表达。方法对66例初步诊断为子宫肌瘤的住院患者及妇科门诊就诊的27例健康女性（ A组：对照组）的静脉血标本作研究，分别检测HE4及CA125。根据术后病理结果将子宫肌瘤患者再分为2个组（ B组：普通型子宫平滑肌瘤组；C组：富于细胞型子宫平滑肌瘤组），对HE4及CA125进行回顾性分析。结果 A、B、C组的血清HE4水平分别为（42．92±8．05）、（50．91±10．00）、（73．98±10．00） pmol/L，组间两两比较，差异均有统计学意义（P＜0．05）。 A、B、C组的血清CA125水平分别为（22．27±14．54）、（21．51±10．88）、（28．42±27．27） U/L，组间差异均无统计学意义（P＞0．05）。结论术前对子宫肌瘤患者进行血清HE4检测，可能有助于术前评估。
목적：초보탐토인부고단백4재자궁부우세포형평활기류중적표체。방법대66례초보진단위자궁기류적주원환자급부과문진취진적27례건강녀성（ A조：대조조）적정맥혈표본작연구，분별검측HE4급CA125。근거술후병리결과장자궁기류환자재분위2개조（ B조：보통형자궁평활기류조；C조：부우세포형자궁평활기류조），대HE4급CA125진행회고성분석。결과 A、B、C조적혈청HE4수평분별위（42．92±8．05）、（50．91±10．00）、（73．98±10．00） pmol/L，조간량량비교，차이균유통계학의의（P＜0．05）。 A、B、C조적혈청CA125수평분별위（22．27±14．54）、（21．51±10．88）、（28．42±27．27） U/L，조간차이균무통계학의의（P＞0．05）。결론술전대자궁기류환자진행혈청HE4검측，가능유조우술전평고。
Objective To explore the expression of serum of Human Epididymis Protein 4(HE4)in cellular uterine leio-myoma.Methods Serum HE4 and CA125 were detected in 66 patients preliminary diagnosed as uterine fibroids and 27 healthy women from gynecological outpatient department ( Group A:control group ) .According to the postoperative pathological results ,u-terine fibroids patients were divided into 2 groups(Group B:common myoma of uterus;group C:the cellular uterine leiomyoma), and HE4 and CA125 were retrospectively analyzed .Results Serum HE4 of the A,B,and C group were 42.92 ±8.05、50.91 ± 10.00、73.98 ±10.00 pmol/L,respectively.There were statistical differences (P<0.05).Serum CA125 of the A,B,and C group were 22.27 ±14.54、21.51 ±10.88、28.42 ±27.27 U/L,respectively.There was no statistical difference (P<0.05).Conclu-sion The detection of HE4 in the uterine fibroids patients before the operation may be helpful for the preoperative evaluation .