CAJ | 학술논문

聚乙烯吡咯烷酮是一种具有优异的化学稳定性、低毒性、生物相溶性的水溶性高分子。采用活性可控聚合方法和原子转移自由基聚合法制备聚乙烯吡咯烷酮，利用基质辅助激光解吸电离飞行时间质谱仪（ MALDI-TOF-MS）和凝胶渗透色谱法（ GPC）分析聚合物的分子量和分子量分布，并比较两者在分析聚合物分子量中的差异。研究表明 MALDI -TOF -MS 方法可直观分析 PNVP 分子链段的结构和重复单元的信息，该方法测定聚合物的分子量与 GPC 测定的分子量相比偏小，造成这种现象的主要原因是分析过程中存在离子歧化现象。
취을희필각완동시일충구유우이적화학은정성、저독성、생물상용성적수용성고분자。채용활성가공취합방법화원자전이자유기취합법제비취을희필각완동，이용기질보조격광해흡전리비행시간질보의（ MALDI-TOF-MS）화응효삼투색보법（ GPC）분석취합물적분자량화분자량분포，병비교량자재분석취합물분자량중적차이。연구표명 MALDI -TOF -MS 방법가직관분석 PNVP 분자련단적결구화중복단원적신식，해방법측정취합물적분자량여 GPC 측정적분자량상비편소，조성저충현상적주요원인시분석과정중존재리자기화현상。
Poly( N-vinylpyrrolidone) ( PNVP) is an attractive water -soluble polymer because of the combi-nation of properties including the chemical stability ,very low toxicity and good biocompatibility .In this pa-per,poly(N-vinylpyrrolidone)(PNVP) was synthesized by living controllable method -atom transfer radi-cal polymerization .The molar mass and the dispersity of molar mass were characterized by MALDI -TOF -MS and GPC.The results confirms that MALDI -TOF-MS can be used to obtain chain structure and the in-formation of repeating units ,and it exhibits narrower dispersity of molecular mass than GPC ,which attributes to the ion disproportionation during the analysis process .