当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2014年
18期
20-21
,共2页
新生儿%脓毒症%毛细血管渗漏%危险因素
新生兒%膿毒癥%毛細血管滲漏%危險因素
신생인%농독증%모세혈관삼루%위험인소
Newborns%Sepsis%Capillary leak%Risk factors
目的：对新生儿脓毒症发生毛细血管渗漏综合征（CLS）的临床危险因素进行分析。方法对2011年6月～2013年6月在深圳市宝安区人民医院接受治疗的30例新生儿发生脓毒症的临床资料进行回顾性分析。30例患儿中15例为一般脓毒症，10例为严重脓毒症，5例为脓毒性休克；再根据患儿是否发生CLS为准，将患儿分为CLS组与非CSL组；在进行单因素分析时，对患儿的年龄、性别、凝血功能障碍等各种相关因素进行了解，自变量为具有统计学意义的相关指标，进而进行回归分析。结果一般脓毒症、严重脓毒症和脓毒性休克患儿的发生率分别为2/15（13.33%）、4/10（40.00%）、4/5（80.00%），差异有统计学意义（P<0.01）；严重脓毒症及休克和PRISM评分是脓毒症患者出现CLS 1的独立危险因素。结论新生儿的脓毒症的严重程度与PRISMⅢ评分呈正比关系，患儿PRISI I评分越高发生CLS的概率就越大。对于脓毒症较严重以及PRISI I评分较高的患儿来说，尽早对其血糖、感染标志物等进行检测，对于判断CLS有积极的帮助，并且能够有效降低儿童脓毒症合并CLS的病死率。
目的：對新生兒膿毒癥髮生毛細血管滲漏綜閤徵（CLS）的臨床危險因素進行分析。方法對2011年6月～2013年6月在深圳市寶安區人民醫院接受治療的30例新生兒髮生膿毒癥的臨床資料進行迴顧性分析。30例患兒中15例為一般膿毒癥，10例為嚴重膿毒癥，5例為膿毒性休剋；再根據患兒是否髮生CLS為準，將患兒分為CLS組與非CSL組；在進行單因素分析時，對患兒的年齡、性彆、凝血功能障礙等各種相關因素進行瞭解，自變量為具有統計學意義的相關指標，進而進行迴歸分析。結果一般膿毒癥、嚴重膿毒癥和膿毒性休剋患兒的髮生率分彆為2/15（13.33%）、4/10（40.00%）、4/5（80.00%），差異有統計學意義（P<0.01）；嚴重膿毒癥及休剋和PRISM評分是膿毒癥患者齣現CLS 1的獨立危險因素。結論新生兒的膿毒癥的嚴重程度與PRISMⅢ評分呈正比關繫，患兒PRISI I評分越高髮生CLS的概率就越大。對于膿毒癥較嚴重以及PRISI I評分較高的患兒來說，儘早對其血糖、感染標誌物等進行檢測，對于判斷CLS有積極的幫助，併且能夠有效降低兒童膿毒癥閤併CLS的病死率。
목적：대신생인농독증발생모세혈관삼루종합정（CLS）적림상위험인소진행분석。방법대2011년6월～2013년6월재심수시보안구인민의원접수치료적30례신생인발생농독증적림상자료진행회고성분석。30례환인중15례위일반농독증，10례위엄중농독증，5례위농독성휴극；재근거환인시부발생CLS위준，장환인분위CLS조여비CSL조；재진행단인소분석시，대환인적년령、성별、응혈공능장애등각충상관인소진행료해，자변량위구유통계학의의적상관지표，진이진행회귀분석。결과일반농독증、엄중농독증화농독성휴극환인적발생솔분별위2/15（13.33%）、4/10（40.00%）、4/5（80.00%），차이유통계학의의（P<0.01）；엄중농독증급휴극화PRISM평분시농독증환자출현CLS 1적독립위험인소。결론신생인적농독증적엄중정도여PRISMⅢ평분정정비관계，환인PRISI I평분월고발생CLS적개솔취월대。대우농독증교엄중이급PRISI I평분교고적환인래설，진조대기혈당、감염표지물등진행검측，대우판단CLS유적겁적방조，병차능구유효강저인동농독증합병CLS적병사솔。
Objective To analyze the clinical risk factors for capillary leak syndrome, neonatal sepsis. Methods Clinical data of 30 cases of neonatal sepsis from June 2011 to June 2013 in the hospital for treatment were retrospectively analyzed. 15 cases were general sepsis patients, 10 patients were severe sepsis, five cases were septic shock;then the children were be divided into groups and the number of cases non-CSL group based on whether children had capillary leak syndrome (CLS);a variety of related factors such as age, gender, coagulation disorders were analyzed, the variable is associated with a statistically significant indicators were done with regression analysis. Results General sepsis, severe sepsis and incidence of septic shock in children were 2/15 (13.33%), 4/10 (40.00%), 4/5 (80.00%), the difference was statistically significant (P<0.01);Severe sepsis and shock and PRISM score were independent risk factors for sepsis patients CLS 1. Conclusion The severity of neonatal sepsis and PRISMⅢscore positive correlation between children PRISIII higher the rating, the greater the probability of occurrence of CLS. For more severe sepsis and PRISIII score higher in children who, as soon as possible for a blood infection and other markers are detected positive for judging CLS help, and can effectively reduce child mortality in sepsis with CLS.
