CAJ | 학술논문

目的：探讨磷酸肌酸钠对老年高血压并心力衰竭（心衰）患者血浆心肌营养素-1（CT-1）、N末端B型利钠肽原（NT-proBNP）水平的影响。方法选择年龄≥65岁的高血压并心衰患者76例，分层随机法分为治疗组和对照组各38例，对照组常规抗心衰治疗，治疗组常规抗心衰治疗加用磷酸肌酸钠，2周后评定2组血浆CT-1、NT-proBNP的变化及心衰症状情况。血浆CT-1水平采用双抗体夹心酶联免疫吸附法（ELISA）测定，NT-proBNP水平采用锐普荧光干式定量分析仪检测。结果治疗后2组血浆CT-1、NT-proBNP水平均较治疗前降低（P＜0.01），治疗组血浆CT-1、NT-proBNP水平较对照组下降更明显（P＜0.05）。治疗组总有效率89.47%，高于对照组的71.05%（P＜0.05）。治疗组1周心衰症状改善21例，2周13例，对照组1周9例，2周18例。结论常规治疗加用磷酸肌酸钠可降低老年高血压并心衰患者血浆CT-1和NT-proBNP水平，在更短的时间内改善患者心力衰竭症状。
목적：탐토린산기산납대노년고혈압병심력쇠갈（심쇠）환자혈장심기영양소-1（CT-1）、N말단B형리납태원（NT-proBNP）수평적영향。방법선택년령≥65세적고혈압병심쇠환자76례，분층수궤법분위치료조화대조조각38례，대조조상규항심쇠치료，치료조상규항심쇠치료가용린산기산납，2주후평정2조혈장CT-1、NT-proBNP적변화급심쇠증상정황。혈장CT-1수평채용쌍항체협심매련면역흡부법（ELISA）측정，NT-proBNP수평채용예보형광간식정량분석의검측。결과치료후2조혈장CT-1、NT-proBNP수평균교치료전강저（P＜0.01），치료조혈장CT-1、NT-proBNP수평교대조조하강경명현（P＜0.05）。치료조총유효솔89.47%，고우대조조적71.05%（P＜0.05）。치료조1주심쇠증상개선21례，2주13례，대조조1주9례，2주18례。결론상규치료가용린산기산납가강저노년고혈압병심쇠환자혈장CT-1화NT-proBNP수평，재경단적시간내개선환자심력쇠갈증상。
Objective To investigate the effect of hosphocreatine therapy on the plasma cardiotrophin-1(CT-1) and N terminal probrain natriuretic (NT-proBNP) in elderly hypertensive patients with heart failure. Methods A total of 76 hy-pertensive patients with heart failure, aged 65 or over, were randomly divided into treatment group and control group (n=38 for each group). The control group received routine anti-heart failure treatment. The treatment group received conventional therapy plus creatine phosphate sodium for 2 weeks. The plasma levels of CT-1 and NT-proBNP were determined in two groups. The plasma CT-1 level was measured by a double antibody sandwich enzyme-linked immunosorbent assay (ELISA). The plasma level of NT-proBNP was tested by Rui Pu fluorescent dry quantitative analyzer. Results The plasma levels of CT-1 and NT-proBNP were significantly lower after treatment in two groups (P<0.01). The plasma levels of CT-1 and NT-proBNP were significantly decreased in treatment group than those in control group (P<0.05). The total effective rate was 89.47%in treatment group, which was significantly higher than that of control group (71.05%, P<0.05). Symptoms of heart failure improved in one week (21 cases in treatment group/9 cases in control group) and in two weeks (13 cases in treatment group/18 cases in control group). Conclusion The conventional therapy plus creatine phosphate sodium can decrease the plasma CT-1 and NT-proBNP levels in elderly hypertensive patients with heart failure, which improves symptoms of heart failure in a shorter period of time.