天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2014年
1期
17-19
,共3页
任静%李刚%张伯玮%张燕雪
任靜%李剛%張伯瑋%張燕雪
임정%리강%장백위%장연설
D-二聚体%静脉血栓栓塞%老年人%排除%临界值%年龄
D-二聚體%靜脈血栓栓塞%老年人%排除%臨界值%年齡
D-이취체%정맥혈전전새%노년인%배제%림계치%년령
D-dimer%venous thromboembolism%aged%rule out%cut-off value%age
目的：分析健康人群和住院患者血浆D-二聚体水平随年龄增长的变化特征，探讨不同年龄段血浆D-二聚体排除诊断老年人静脉血栓栓塞（VTE）的临界值。方法选择健康体检者6717例和住院患者2976例。采用法国生物梅里埃VIDAS荧光免疫分析仪测定血浆D-二聚体水平。结果40岁以上健康人群随年龄增长，血浆D-二聚体水平显著增高（P<0.01），住院患者各年龄组血浆D-二聚体水平存在同样变化趋势，VTE发生率也随年龄增加而增加。D-二聚体诊断≤40岁组患者VTE的临界值为504μg/L，敏感度为100.0%；41~60岁组的临界值为565μg/L，敏感度为96.2%；61~74岁组的临界值为817μg/L，敏感度为80.8%；≥75岁组的临界值为1024μg/L，敏感度为73.1%。结论血浆D-二聚体水平随年龄的增长而增高，老年患者D-二聚体排除诊断VTE的临界值高于其他年龄组，但诊断敏感度显著下降。
目的：分析健康人群和住院患者血漿D-二聚體水平隨年齡增長的變化特徵，探討不同年齡段血漿D-二聚體排除診斷老年人靜脈血栓栓塞（VTE）的臨界值。方法選擇健康體檢者6717例和住院患者2976例。採用法國生物梅裏埃VIDAS熒光免疫分析儀測定血漿D-二聚體水平。結果40歲以上健康人群隨年齡增長，血漿D-二聚體水平顯著增高（P<0.01），住院患者各年齡組血漿D-二聚體水平存在同樣變化趨勢，VTE髮生率也隨年齡增加而增加。D-二聚體診斷≤40歲組患者VTE的臨界值為504μg/L，敏感度為100.0%；41~60歲組的臨界值為565μg/L，敏感度為96.2%；61~74歲組的臨界值為817μg/L，敏感度為80.8%；≥75歲組的臨界值為1024μg/L，敏感度為73.1%。結論血漿D-二聚體水平隨年齡的增長而增高，老年患者D-二聚體排除診斷VTE的臨界值高于其他年齡組，但診斷敏感度顯著下降。
목적：분석건강인군화주원환자혈장D-이취체수평수년령증장적변화특정，탐토불동년령단혈장D-이취체배제진단노년인정맥혈전전새（VTE）적림계치。방법선택건강체검자6717례화주원환자2976례。채용법국생물매리애VIDAS형광면역분석의측정혈장D-이취체수평。결과40세이상건강인군수년령증장，혈장D-이취체수평현저증고（P<0.01），주원환자각년령조혈장D-이취체수평존재동양변화추세，VTE발생솔야수년령증가이증가。D-이취체진단≤40세조환자VTE적림계치위504μg/L，민감도위100.0%；41~60세조적림계치위565μg/L，민감도위96.2%；61~74세조적림계치위817μg/L，민감도위80.8%；≥75세조적림계치위1024μg/L，민감도위73.1%。결론혈장D-이취체수평수년령적증장이증고，노년환자D-이취체배제진단VTE적림계치고우기타년령조，단진단민감도현저하강。
Objective To investigate the plasma level of D-dimer in healthy population and hospitalized patients, and to analyze the cut-off value of D-dimer levels in different age groups for the exclusion of venous thromboembolism (VTE) in older patients. Methods A total of 6 717 healthy individuals and 2 976 hospitalized patients were included in the study. The blood level of D-dimer was detected by the Biomerieux VIDAS fluor-euzymelinked immunoassay analyzer assay. Results The blood level of D-dimer was significantly increased with age in healthy people aged over 40 and different age groups of hospitalized patients (P<0.01). The incidence of venous thromboembolism was also increased with age. The cut-off value for the diagnosis of VTE with D-dimer was 504 μg/L in patient group aged ≤40 years, and the sensitivity was 100.0%. The cut-off value was 565μg/L in 41~60-year group, and the sensitivity was 96.2%. The cut-off value was 817μg/L in 61~74-year group, and the sensitivity was 80.8%. The cut-off value was 1 024μg/L in≥75-year group, and the sensitivity was 73.1%. Conclusion The plasma D-dimer level increased with age. The D-dimer cur-off value was higher in older patients than that of other age groups, but the sensitivity in diagnosis was decreased obviously.
