林产化学与工业
林產化學與工業
림산화학여공업
CHEMISTRY AND INDUSTRY OF FOREST PRODUCTS
2014年
1期
128-134
,共7页
蕈类%抗肿瘤%多糖%研究
蕈類%抗腫瘤%多糖%研究
심류%항종류%다당%연구
mushroom%anti-tumor%polysaccharide%study
蕈类被视为功能性食物，具有营养和药用价值，多糖是蕈类中的主要活性物质，具有抗肿瘤和增强免疫的作用。蕈类多糖由于来源广泛，其在化学结构和抗肿瘤活性方面存在较大差异。文章从具有抗肿瘤活性的蕈类多糖、抗肿瘤蕈类多糖的结构特征、蕈类多糖结构与抗肿瘤活性的关系、蕈类多糖的抗肿瘤作用及机制4个方面综述了抗肿瘤蕈类多糖的研究进展。并进一步从多糖受体相关的信号转导通路研究、构效关系研究、代谢动力学研究3个方面进行了展望。
蕈類被視為功能性食物，具有營養和藥用價值，多糖是蕈類中的主要活性物質，具有抗腫瘤和增彊免疫的作用。蕈類多糖由于來源廣汎，其在化學結構和抗腫瘤活性方麵存在較大差異。文章從具有抗腫瘤活性的蕈類多糖、抗腫瘤蕈類多糖的結構特徵、蕈類多糖結構與抗腫瘤活性的關繫、蕈類多糖的抗腫瘤作用及機製4箇方麵綜述瞭抗腫瘤蕈類多糖的研究進展。併進一步從多糖受體相關的信號轉導通路研究、構效關繫研究、代謝動力學研究3箇方麵進行瞭展望。
심류피시위공능성식물，구유영양화약용개치，다당시심류중적주요활성물질，구유항종류화증강면역적작용。심류다당유우래원엄범，기재화학결구화항종류활성방면존재교대차이。문장종구유항종류활성적심류다당、항종류심류다당적결구특정、심류다당결구여항종류활성적관계、심류다당적항종류작용급궤제4개방면종술료항종류심류다당적연구진전。병진일보종다당수체상관적신호전도통로연구、구효관계연구、대사동역학연구3개방면진행료전망。
Mushrooms are recognized as functional foods and have credible nutritional and medicinal values. Polysaccharide is one of the most bioactive components in mushrooms and exhibits anti-tumor and immunostimulating activities. Numerous polysaccharides with anti-tumor activity have been extracted from a variety of mushrooms, but there are many differences in their chemical composition, structure and anti-tumor activity. This review aims to integrate the R&D progress of anti-tumor polysaccharides in mushrooms which include mushroom polysaccharides with anti-tumor activity, chemistry of mushroom polysaccharides, relationship between structure and anti-tumor activities of mushroom polysaccharides, anti-tumor activity and mechanisms of mushroom polysaccharides. And this review also looks forward to the future studies on receptors and signal transduction pathway, structure activity relationship and pharmacokinetics of polysaccharides.
