CAJ | 학술논문

目的：观察藏药十味乳香散内服合五味甘露药浴局部熏洗治疗痛风性关节炎的临床疗效。方法：将80例患者随机分为治疗组、对照组各40例。对照组采用西药治疗：秋水仙碱：开始0.5 mg，1小时后再服用0.25 mg，2次/d，1～2 d，症状缓解后改为0.25～0.5 mg/d，共服1周，同时口服别嘌呤醇，0.1 g/次，3次/d，疗程2周。治疗组采用藏药治疗：十味乳香散，1 g/次，3次/d，饭后服，连续用药2周；五味甘露药浴配方熏洗患处2周，1次/d。观察2组关节红肿消失时间、疼痛缓解时间及治疗前后血沉、血清C反应蛋白、血尿酸、血液流变学变化情况。结果：2组治疗后关节红肿、疼痛均有缓解，治疗组缓解较对照组快，差异有统计学意义(P＜0.05)。2组血尿酸、血沉及C反应蛋白治疗前较治疗后都有明显降低(P＜0.05)；治疗后组间比较，治疗组降低较对照组明显(P＜0.05)。对照组治疗后血液流变学指标无显改善(P＞0.05)，治疗组治疗后血液流变学指标改善明显(P＜0.05)；治疗后组间比较，治疗组较对照组明显降低(P＜0.05)。结论：藏药十味乳香散内服合五味甘露药浴局部熏洗治疗痛风性关节炎临床疗效显著。
목적：관찰장약십미유향산내복합오미감로약욕국부훈세치료통풍성관절염적림상료효。방법：장80례환자수궤분위치료조、대조조각40례。대조조채용서약치료：추수선감：개시0.5 mg，1소시후재복용0.25 mg，2차/d，1～2 d，증상완해후개위0.25～0.5 mg/d，공복1주，동시구복별표령순，0.1 g/차，3차/d，료정2주。치료조채용장약치료：십미유향산，1 g/차，3차/d，반후복，련속용약2주；오미감로약욕배방훈세환처2주，1차/d。관찰2조관절홍종소실시간、동통완해시간급치료전후혈침、혈청C반응단백、혈뇨산、혈액류변학변화정황。결과：2조치료후관절홍종、동통균유완해，치료조완해교대조조쾌，차이유통계학의의(P＜0.05)。2조혈뇨산、혈침급C반응단백치료전교치료후도유명현강저(P＜0.05)；치료후조간비교，치료조강저교대조조명현(P＜0.05)。대조조치료후혈액류변학지표무현개선(P＞0.05)，치료조치료후혈액류변학지표개선명현(P＜0.05)；치료후조간비교，치료조교대조조명현강저(P＜0.05)。결론：장약십미유향산내복합오미감로약욕국부훈세치료통풍성관절염림상료효현저。
Objective: To observe clinical effects of Tibetan medicine ShiWei RuXiangSan for oral administration and WuWei GanLu for local fumigation in treating gouty arthritis. Methods: Eighty patients were separated into the treatment group and the control group. The control group accepted western medicine:colchicines:start with 0.5 mg, taking 0.25mg in one hour, twice per day, one to two days, when the patients were relieved, the dose was changed into 0.25~0.5mg each day, for one week, at the same time, allopurinol orally, 0.1g each time, three times per day, one course of treatment was two weeks. The treatment group accepted Tibetan medicine: ShiWei RuXiangSan, 1 g each time, three times per day, taking after the meal, for two consecutive weeks;WuWei GanLu for local fumigation, two weeks, once per day. The disappearing time of joint swelling, pain remission time and the changes of erythrocyte sedimentation rate (ESR), C reactive protein (CRP) in the serum, blood uric acid (BUA) and blood rheology were observed. Results:Joint swelling and pain in both groups were alleviated after treating, the re-mission of the treatment group was faster than that of the control group, the difference presented statistical meaning (P<0.05). BUA, ESR and CRP of both groups before treating were lower than these indexes after treating obviously (P<0.05);after treating, the decrease of the treatment group was more obvious than that of the control group (P<0.05). The indexes of blood rheology in the control group were improved obviously (P>0.05), and these of the treatment group were improved notably (P<0.05);after treating, the treatment group was lower than the control group (P<0.05). Conclusion:Tibetan medicine ShiWei RuXiangSan for oral administration and WuWei GanLu for local fumigation are effective in treating gouty arthritis.