CAJ | 학술논문

卵巢粒层细胞瘤(GCT)是一种少见的卵巢功能性肿瘤，占卵巢肿瘤的2%~5%。卵巢 GCT按照组织病理学类型分为成年型 GCT(AGCT)及幼年型 GCT(JGCT)，其病因迄今尚未阐明。其临床上最常见临床症状为雌激素刺激症状。手术是卵巢GCT的首选治疗方法。卵巢GCT具有远期复发特点，目前认为其临床分期是影响患者预后最重要的因素，抑制素(inhibin)水平、抗苗勒管激素(AMH)等可作为诊断卵巢 GCT的血清学标志物，为其复发提供一定的临床病理学诊断参考。研究发现，在 AGCT 中，翼状螺旋/叉头转录因子(FOXL)2基因中存在一个单一、复发的体细胞突变(402C→G)，而在JGCT 患者中却少有该突变。FOXL2及其突变体对卵巢 GCT发展的病理生理作用，迄今尚不清楚。总之，卵巢 GCT患者的总体预后较好，而复发患者的预后相对较差，因其具有远期复发特点，所以应对该病患者坚持长期随访。
란소립층세포류(GCT)시일충소견적란소공능성종류，점란소종류적2%~5%。란소 GCT안조조직병이학류형분위성년형 GCT(AGCT)급유년형 GCT(JGCT)，기병인흘금상미천명。기림상상최상견림상증상위자격소자격증상。수술시란소GCT적수선치료방법。란소GCT구유원기복발특점，목전인위기림상분기시영향환자예후최중요적인소，억제소(inhibin)수평、항묘륵관격소(AMH)등가작위진단란소 GCT적혈청학표지물，위기복발제공일정적림상병이학진단삼고。연구발현，재 AGCT 중，익상라선/차두전록인자(FOXL)2기인중존재일개단일、복발적체세포돌변(402C→G)，이재JGCT 환자중각소유해돌변。FOXL2급기돌변체대란소 GCT발전적병리생리작용，흘금상불청초。총지，란소 GCT환자적총체예후교호，이복발환자적예후상대교차，인기구유원기복발특점，소이응대해병환자견지장기수방。
Ovarian granulosa cell tumor (GCT),a group of low grade and potential recurrence functional tumor,with the adult GCT (AGCT)and juvenile GCT(JGCT).Ovarian GCT is one of the ovarial sex cord stromal tumors,accounting for 2%-5% of ovarial tumors.Etiology of GCT is still unclear.The most common symptom of GCT patients was menstrual disorder or abnormal vaginal bleeding.Surgery is the mainstay of initial management for patients with a suspected GCT.Ovarian GCT are characterized with recurrence.Stages of GCT are always indicative to be prognosis factors.Inhibin and anti-Mullerian hormone (AMH)were reported to have a certain value for diagnosis and follow-up of GCT.A single recurrent somatic mutation of forkhead transcription factor (FOXL)2 gene c.402C→G in whole transcriptome sequencing of FOXL2 gene in AGCT.While the mutation were absent in JGCT patients.To date,its biological role of this mutation is yet unclear.In summary,patients with early stage of GCT have an excellent prognosis.Recurrence of GCT is associated with a poor prognosis.For its long-term recurrence, long-term follow-up is needed.