国际生物制品学杂志
國際生物製品學雜誌
국제생물제품학잡지
INTERNATIONAL JOURNAL OF BIOLOGICALS
2013年
2期
96-99
,共4页
白细胞介素6%受体,白细胞介素6%分子靶向治疗
白細胞介素6%受體,白細胞介素6%分子靶嚮治療
백세포개소6%수체,백세포개소6%분자파향치료
Interleukin-6%Receptors,interleukin-6%Molecular targeted therapy
白细胞介素6(interleukin-6,IL-6)是多效性细胞因子,参与机体的免疫反应、血细胞生成、急性期反应、骨代谢调节等.IL-6功能的行使需要IL-6受体的参与.越来越多的研究证明,IL-6的超表达与多种疾病的发生密切相关.所以,靶向IL-6药物的研发成为人们关注的焦点.此文就IL-6及其受体的结构、IL-6的相关功能、IL-6与疾病的关系及靶向IL-6药物的研究现状作简要综述.
白細胞介素6(interleukin-6,IL-6)是多效性細胞因子,參與機體的免疫反應、血細胞生成、急性期反應、骨代謝調節等.IL-6功能的行使需要IL-6受體的參與.越來越多的研究證明,IL-6的超錶達與多種疾病的髮生密切相關.所以,靶嚮IL-6藥物的研髮成為人們關註的焦點.此文就IL-6及其受體的結構、IL-6的相關功能、IL-6與疾病的關繫及靶嚮IL-6藥物的研究現狀作簡要綜述.
백세포개소6(interleukin-6,IL-6)시다효성세포인자,삼여궤체적면역반응、혈세포생성、급성기반응、골대사조절등.IL-6공능적행사수요IL-6수체적삼여.월래월다적연구증명,IL-6적초표체여다충질병적발생밀절상관.소이,파향IL-6약물적연발성위인문관주적초점.차문취IL-6급기수체적결구、IL-6적상관공능、IL-6여질병적관계급파향IL-6약물적연구현상작간요종술.
Interleukin-6 (IL-6) is a multifunctional cytokine,which involves in immune responses,hemopoiesis,acute phase reaction,and regulation of bone metabolism.IL-6 receptors are necessary for exerting function of IL-6.More and more researches show that IL-6 overexpression is closely associated with many diseases.Therefore,development of drugs targeted IL-6 has become the main focus of attention.In this paper,structure of the IL-6 and its receptors,functions of IL-6,relationship between IL-6 and diseases and current research of drugs targeted IL-6 are reviewed.
