CAJ | 학술논문

研究了以水为溶剂，四丁基溴化铵（ TBAB）为相转移催化剂，对甲苯磺酰胺为原料，高锰酸钾为氧化剂，合成药物中间体4-羧基苯磺酰胺的新工艺．考察了碱的用量、催化剂用量、反应温度、高锰酸钾与对甲基苯磺酰胺的摩尔比、反应时间等因素对反应收率的影响．较适宜条件为在40 mL水为溶剂，对甲基苯磺酰胺3.5 g，氢氧化钠用量为1.2 g， TBAB的用量为0.1 g，高锰酸钾与对甲基苯磺酰胺的摩尔比为2.0，反应温度70℃，反应时间2.5 h，4-羧基苯磺酰胺的产率可达93.6％．该方法具有反应条件温和、反应时间较短、操作简单和收率高等特点．
연구료이수위용제，사정기추화안（ TBAB）위상전이최화제，대갑분광선알위원료，고맹산갑위양화제，합성약물중간체4-최기분광선알적신공예．고찰료감적용량、최화제용량、반응온도、고맹산갑여대갑기분광선알적마이비、반응시간등인소대반응수솔적영향．교괄의조건위재40 mL수위용제，대갑기분광선알3.5 g，경양화납용량위1.2 g， TBAB적용량위0.1 g，고맹산갑여대갑기분광선알적마이비위2.0，반응온도70℃，반응시간2.5 h，4-최기분광선알적산솔가체93.6％．해방법구유반응조건온화、반응시간교단、조작간단화수솔고등특점．
The synthesis 4-carboxybenzenesulfonamide was investigated with TBAB as catalyst, 4-methyl-benzenesulfonamide as raw material, potassium permanganate as the oxidant and H2 O as solvent.The influen-cing factors were inspected through a series of experiments.When the mixture of 4-tolylsulfonamide 3.5 g, so-dium hydroxide 1.2 g, TBAB 0.1 g and potassium permanganate 6.5 g was stirred in 40mL water at 70℃for 2.5 h, 4-carboxybenzenesulfonamide was obtained in the yield of 93.6%.The improved method will be good industrial application prospect because of the mild reaction condition, short reaction time, excellent yield, simple operation and reduced cost.