中国现代医药杂志
中國現代醫藥雜誌
중국현대의약잡지
MODERN MEDICINE JOURNAL OF CHINA
2014年
9期
47-49
,共3页
子宫内膜样腺癌%鳞状上皮分化%病理特征%预后分析
子宮內膜樣腺癌%鱗狀上皮分化%病理特徵%預後分析
자궁내막양선암%린상상피분화%병리특정%예후분석
Endometrial adenocarcinoma%Squamous epithelial differentiation%Pathologitcal feature%Prognosis analysis
目的：分析并评价子宫内膜样腺癌并发鳞状上皮分化患者的临床病理学特点及预后状况。方法选择48例子宫内膜样腺癌伴鳞状上皮分化患者作为观察组，同期住院的59例子宫内膜样腺癌不伴有鳞状上皮分化患者作为对照组，对比分析两组临床病理特征、治疗及预后状况。结果两组患者在年龄与临床病理特征方面相比无统计学差异（P>0.05）；两组间肿瘤分期均接近（P 均>0.05）；观察组肿瘤高分化程度显著低于对照组（P=0.008），存在统计学意义；其中的中分化及低分化肿瘤比例均高于对照组，但未见统计学差异（P 均>0.05）；观察组浸润肌层程度≥1/2者少于对照组（P>0.05）；两组淋巴结转移状况间比较无明显差异（P>0.05），不具有统计学意义。两组间手术治疗及辅助治疗方法相比无明显差异（P均>0.05），不具有统计学意义。两组平均随访（31.6±17.5）个月，观察组死亡与复发占8.33％，对照组占5.08％，两组相比无明显差异（P>0.05），不具有统计学意义。结论子宫内膜样腺癌并发鳞状上皮分化主要为中低分化类型，但同单纯子宫内膜样腺癌患者相比，其病理学特征及预后并无显著性差异，两者临床治疗方法基本相同。
目的：分析併評價子宮內膜樣腺癌併髮鱗狀上皮分化患者的臨床病理學特點及預後狀況。方法選擇48例子宮內膜樣腺癌伴鱗狀上皮分化患者作為觀察組，同期住院的59例子宮內膜樣腺癌不伴有鱗狀上皮分化患者作為對照組，對比分析兩組臨床病理特徵、治療及預後狀況。結果兩組患者在年齡與臨床病理特徵方麵相比無統計學差異（P>0.05）；兩組間腫瘤分期均接近（P 均>0.05）；觀察組腫瘤高分化程度顯著低于對照組（P=0.008），存在統計學意義；其中的中分化及低分化腫瘤比例均高于對照組，但未見統計學差異（P 均>0.05）；觀察組浸潤肌層程度≥1/2者少于對照組（P>0.05）；兩組淋巴結轉移狀況間比較無明顯差異（P>0.05），不具有統計學意義。兩組間手術治療及輔助治療方法相比無明顯差異（P均>0.05），不具有統計學意義。兩組平均隨訪（31.6±17.5）箇月，觀察組死亡與複髮佔8.33％，對照組佔5.08％，兩組相比無明顯差異（P>0.05），不具有統計學意義。結論子宮內膜樣腺癌併髮鱗狀上皮分化主要為中低分化類型，但同單純子宮內膜樣腺癌患者相比，其病理學特徵及預後併無顯著性差異，兩者臨床治療方法基本相同。
목적：분석병평개자궁내막양선암병발린상상피분화환자적림상병이학특점급예후상황。방법선택48례자궁내막양선암반린상상피분화환자작위관찰조，동기주원적59례자궁내막양선암불반유린상상피분화환자작위대조조，대비분석량조림상병리특정、치료급예후상황。결과량조환자재년령여림상병리특정방면상비무통계학차이（P>0.05）；량조간종류분기균접근（P 균>0.05）；관찰조종류고분화정도현저저우대조조（P=0.008），존재통계학의의；기중적중분화급저분화종류비례균고우대조조，단미견통계학차이（P 균>0.05）；관찰조침윤기층정도≥1/2자소우대조조（P>0.05）；량조림파결전이상황간비교무명현차이（P>0.05），불구유통계학의의。량조간수술치료급보조치료방법상비무명현차이（P균>0.05），불구유통계학의의。량조평균수방（31.6±17.5）개월，관찰조사망여복발점8.33％，대조조점5.08％，량조상비무명현차이（P>0.05），불구유통계학의의。결론자궁내막양선암병발린상상피분화주요위중저분화류형，단동단순자궁내막양선암환자상비，기병이학특정급예후병무현저성차이，량자림상치료방법기본상동。
Objective To analyze and evaluate the clinical pathological features and prognosis of endometrial adenocar-cinoma with squamous epithelial differentiation. Methods Selected 48 endometrial adenocarcinoma patients with squamous differentiation as observation group,59 endometrial adenocarcinoma patients without squamous epithelial differentiation at the same period as control group,compared the clinical pathological characteristics,treatment and prognosis between two groups. Results There was no statistical difference in the age,the clinical pathologic characteristics and cancer stage between two groups (P>0.05). The high degree of differentiation of tumor in observation group was significantly lower than that of the control group (P=0.008). The proportion of moderate and low differentiated tumors in observation group were higher than the control group,but it had no statistical difference (P>0.05). Patients with muscular infiltration degree equal to or greater than 1/2 was fewer in observation group than the control group (P>0.05). There was no significant difference between the two groups on lymph node metastasis, surgical treatment and auxiliary treatment (P>0.05). The average follow-up period of two groups was 31.6±17.5 months. There was no statistical difference between the rate of death and recurrence in observation group (8.33%) and the con-trol group (5.08%),P>0.05. Conclusion Endometrial adenocarcinoma with squamous differentiation mainly occurs in the moderate and low differentiated tumors. However,its clinical treatment,prognosis and clinical treatment are the same as endome-trial adenocarcinoma.
