CAJ | 학술논문

视网膜静脉阻塞(RVO)常因黄斑水肿和新生血管性青光眼等严重并发症导致视力下降甚至失明,是仅次于糖尿病视网膜病变的第二位致盲性视网膜血管疾病,是临床诊断和治疗的难点之一.研究表明,本病系多因素、多环节致病,尽管随着医学基础研究和实验技术的发展,对RVO的研究不断深入,但目前其发病机制尚未完全明确,治疗效果尚不肯定.多年来,国内外学者在RVO的病因学、病理学和治疗学等方面建立了多种动物模型.就各种不同模型的制作方法进行归纳和比较,探讨其病理改变的特点,为研究者根据不同研究目的选择合适的动物模型及探讨新的治疗手段提供参考依据.
시망막정맥조새(RVO)상인황반수종화신생혈관성청광안등엄중병발증도치시력하강심지실명,시부차우당뇨병시망막병변적제이위치맹성시망막혈관질병,시림상진단화치료적난점지일.연구표명,본병계다인소、다배절치병,진관수착의학기출연구화실험기술적발전,대RVO적연구불단심입,단목전기발병궤제상미완전명학,치료효과상불긍정.다년래,국내외학자재RVO적병인학、병이학화치료학등방면건립료다충동물모형.취각충불동모형적제작방법진행귀납화비교,탐토기병리개변적특점,위연구자근거불동연구목적선택합괄적동물모형급탐토신적치료수단제공삼고의거.
Retinal vein occlusion(RVO) is a common retinal vascular disorder that frequently leads to severe vision loss and even blindness due to its complications,such as macular edema and neovascular glaucoma.It is the second leading cause of vascular eye disease behind only diabetic retinopathy.Currently there still is no definite efficacy in treatment for this disease.Researches showed that this disease is a multi-factor and link pathogenic process.Animal models could be potentially of helpful for researching the etiology,pathology and developing new treatments.This paper summarizes the different manufacture methods of the animal models,discusses the pathological changes and chooses the appropriate animal models for different research purposes and offers a good experimental basis to develop new treatments.