CAJ | 학술논문

本研究对我院电镜室收集的12，332例肾活检标本进行透射电镜观察，对超微结构表现特殊有形结构或形成特殊形态沉积的肾脏病进行超微病理特点分析，根据电镜在其病理诊断中的作用分为三类：分别为决定性诊断作用、重要诊断价值和辅助参考作用。结果显示，肾组织内特殊有形结构形成的肾脏病占肾活检病例的1?65％，其中，以淀粉样变为最常见，其次为冷球蛋白血症肾损害。电镜检查对于大多数超微结构表现特殊有形结构的肾脏病的诊断具有重要诊断价值；尤其是对于早期淀粉样变、纤维样和免疫触须样肾小球病、致密物沉积病和Fabry氏病的诊断具有决定性诊断作用。
본연구대아원전경실수집적12，332례신활검표본진행투사전경관찰，대초미결구표현특수유형결구혹형성특수형태침적적신장병진행초미병리특점분석，근거전경재기병리진단중적작용분위삼류：분별위결정성진단작용、중요진단개치화보조삼고작용。결과현시，신조직내특수유형결구형성적신장병점신활검병례적1?65％，기중，이정분양변위최상견，기차위랭구단백혈증신손해。전경검사대우대다수초미결구표현특수유형결구적신장병적진단구유중요진단개치；우기시대우조기정분양변、섬유양화면역촉수양신소구병、치밀물침적병화Fabry씨병적진단구유결정성진단작용。
A total of 12332 cases of renal biopsies collected from Peking University First Hospital from 1995 to 2006 were studied by transmission electron microscopy (EM). 203 cases of them (1?65%) were found to have specific organized deposits ultrastructurally. The most common disease was renal amyloidosis, and the followed one was cryoglobulinemia related glomerulonephritis. The roles of EM in the diagnosis of renal diseases were divided into three groups:crucial role, important contribution, and auxiliary contribution. EM made an important contribution to the diagnosis of the majority of renal diseases with organized deposits, and it played a crucial role in the diagnosis of early amyloidosis, fibrillary and immunotactoid glomerulopathy, dense deposit disease, and Fabry disease.