中国中医药信息杂志
中國中醫藥信息雜誌
중국중의약신식잡지
CHINESE JOURNAL OF INFORMATION ON TRADITIONAL CHINESE MEDICINE
2014年
6期
18-20
,共3页
高血压病%化痰通络%痰瘀互结%血管内皮生长因子
高血壓病%化痰通絡%痰瘀互結%血管內皮生長因子
고혈압병%화담통락%담어호결%혈관내피생장인자
hypertension%resolving phlegm and dredging collaterals%accumulation of phlegm and blood stasis%vascular endothelial growth factor
目的：观察化痰通络中药治疗痰瘀互结型高血压病的临床疗效及其对血管内皮生长因子(VEGF)的影响。方法将68例痰瘀互结型高血压患者随机分为2组,对照组(34例)给予硝苯地平控释片,治疗组(34例)在对照组治疗基础上加用化痰通络中药,疗程均为12周。观察2组的降压疗效,并比较2组治疗前后血压、中医证候积分、血清VEGF 水平。结果对照组、治疗组降压总有效率分别为79.4%(27/34)、91.2%(31/34),2组比较差异有统计学意义(P＜0.05)。2组治疗后收缩压、舒张压、中医证候积分、血清VEGF水平均较治疗前明显下降(P＜0.01),治疗组各项指标均优于对照组(P＜0.05),且不良反应发生例数少。结论化痰通络中药配合降压药治疗痰瘀互结型高血压病的降压疗效显著,可改善患者临床症状,降低血清 VEGF 水平,在一定程度上改善血管内皮功能。
目的：觀察化痰通絡中藥治療痰瘀互結型高血壓病的臨床療效及其對血管內皮生長因子(VEGF)的影響。方法將68例痰瘀互結型高血壓患者隨機分為2組,對照組(34例)給予硝苯地平控釋片,治療組(34例)在對照組治療基礎上加用化痰通絡中藥,療程均為12週。觀察2組的降壓療效,併比較2組治療前後血壓、中醫證候積分、血清VEGF 水平。結果對照組、治療組降壓總有效率分彆為79.4%(27/34)、91.2%(31/34),2組比較差異有統計學意義(P＜0.05)。2組治療後收縮壓、舒張壓、中醫證候積分、血清VEGF水平均較治療前明顯下降(P＜0.01),治療組各項指標均優于對照組(P＜0.05),且不良反應髮生例數少。結論化痰通絡中藥配閤降壓藥治療痰瘀互結型高血壓病的降壓療效顯著,可改善患者臨床癥狀,降低血清 VEGF 水平,在一定程度上改善血管內皮功能。
목적：관찰화담통락중약치료담어호결형고혈압병적림상료효급기대혈관내피생장인자(VEGF)적영향。방법장68례담어호결형고혈압환자수궤분위2조,대조조(34례)급여초분지평공석편,치료조(34례)재대조조치료기출상가용화담통락중약,료정균위12주。관찰2조적강압료효,병비교2조치료전후혈압、중의증후적분、혈청VEGF 수평。결과대조조、치료조강압총유효솔분별위79.4%(27/34)、91.2%(31/34),2조비교차이유통계학의의(P＜0.05)。2조치료후수축압、서장압、중의증후적분、혈청VEGF수평균교치료전명현하강(P＜0.01),치료조각항지표균우우대조조(P＜0.05),차불량반응발생례수소。결론화담통락중약배합강압약치료담어호결형고혈압병적강압료효현저,가개선환자림상증상,강저혈청 VEGF 수평,재일정정도상개선혈관내피공능。
Objective To observe the clinical efficacy of Chinese medicine of resolving phlegm and dredging collaterals in treating hypertension, and its effect on vascular endothelial growth factor (VEGF). Methods Sixty-eight hypertension patients with accumulation of phlegm and blood stasis were randomly divided into two groups, 34 cases of control group received Nifedipine controlled-release tablets, 34 cases of treatment group received Chinese medicine of resolving phlegm and dredging collaterals additionally, with treatment course of 12 weeks. Antihypertensive efficacy of the two groups was observed, and blood pressure, TCM symptom score and serum VEGF level of two groups before and after treatment were compared. Results The total effective rate of the control group and the treatment group was 79.4%(27/34) and 91.2%(31/34) respectively, the difference between them was significant (P<0.05). After treatment, SBP, DBP, TCM syndrome score and serum VEGF level of the two groups were significantly decreased (P<0.01). The indexes of the treatment group was better than the control group (P<0.05), and the cases with adverse reaction of the treatment group was less than the control group. Conclusion Chinese medicine of resolving phlegm and dredging collaterals has significant antihypertensive effect in treating hypertension with accumulation of phlegm and blood stasis, can improve patients' clinical symptoms, reduce serum VEGF level, thus improve vascular endothelial function to some extent.
