中国肿瘤临床
中國腫瘤臨床
중국종류림상
CHINESE JOURNAL OF CLINICAL ONCOLOGY
2014年
7期
480-483
,共4页
谢萍%王茂梅(综述)%熊小亮(审校)
謝萍%王茂梅(綜述)%熊小亮(審校)
사평%왕무매(종술)%웅소량(심교)
GLI1%肿瘤%侵袭%转移%EMT
GLI1%腫瘤%侵襲%轉移%EMT
GLI1%종류%침습%전이%EMT
GLI1%tumor invasion%metastasis%EMT
哺乳动物Hedgehog基因家族包括3个成员:Sonic hedgehog(SHH)、Desert hedgehog(DHH)和Indian hedgehog(IHH)。SHH信号通路主要由分泌型信号糖蛋白SHH配体、跨膜蛋白受体PTCH和另一跨膜蛋白SMO的复合物,以及3种GLI蛋白的下游转录因子GLI1、GLI2、GLI3组成。作为最经典的信号通路之一,SHH信号通路在胚胎发生、发育和组织更新等过程中发挥至关重要作用。GLI1是该通路中最重要转录因子之一,其异常活化与纤维化修复、肿瘤的发生发展与侵袭转移、肿瘤耐药和预后等密切相关。本文就GLI1与肿瘤发生与侵袭转移作用机制进行综述。
哺乳動物Hedgehog基因傢族包括3箇成員:Sonic hedgehog(SHH)、Desert hedgehog(DHH)和Indian hedgehog(IHH)。SHH信號通路主要由分泌型信號糖蛋白SHH配體、跨膜蛋白受體PTCH和另一跨膜蛋白SMO的複閤物,以及3種GLI蛋白的下遊轉錄因子GLI1、GLI2、GLI3組成。作為最經典的信號通路之一,SHH信號通路在胚胎髮生、髮育和組織更新等過程中髮揮至關重要作用。GLI1是該通路中最重要轉錄因子之一,其異常活化與纖維化脩複、腫瘤的髮生髮展與侵襲轉移、腫瘤耐藥和預後等密切相關。本文就GLI1與腫瘤髮生與侵襲轉移作用機製進行綜述。
포유동물Hedgehog기인가족포괄3개성원:Sonic hedgehog(SHH)、Desert hedgehog(DHH)화Indian hedgehog(IHH)。SHH신호통로주요유분비형신호당단백SHH배체、과막단백수체PTCH화령일과막단백SMO적복합물,이급3충GLI단백적하유전록인자GLI1、GLI2、GLI3조성。작위최경전적신호통로지일,SHH신호통로재배태발생、발육화조직경신등과정중발휘지관중요작용。GLI1시해통로중최중요전록인자지일,기이상활화여섬유화수복、종류적발생발전여침습전이、종류내약화예후등밀절상관。본문취GLI1여종류발생여침습전이작용궤제진행종술。
The mammalian animal gene family Hedgehog includes three members, namely, Sonic hedgehog (SHH), Desert hedgehog, and Indian hedgehog. As one of the classical signaling pathways, the SHH signaling pathway has a crucial function in the processes of embryogenesis, development, and tissue regeneration. GLI1 is one of the most important transcription factors in this path-way. Abnormal GLI1 activation is closely related to fibrosis repair, tumorigenesis, invasion and metastasis of tumors, and tumor drug re-sistance and prognosis. This article briefly describes the relationship among GLI1, tumorigenesis, and tumor development.