CAJ | 학술논문

动脉粥样硬化(AS)是心脑血管疾病主要的病理基础，而心脑血管疾病严重危害人类健康，虽然其发病机制尚未完全阐明，但有很多证据表明， AS是一种慢性炎症疾病，在AS斑块的形成、进展、不稳定性斑块破裂和血栓形成中炎症起着非常重要作用。涉及到肿瘤坏死因子(TNF-α)、C-反应蛋白、同型半胱氨酸、纤维蛋白酶原、IL-6、IL-8、IL-18、IFN-γ、ICAM-1、MCP-1等，本文就炎性因子在动脉粥样硬化的形成及发展中的作用及机制作一综述。
동맥죽양경화(AS)시심뇌혈관질병주요적병리기출，이심뇌혈관질병엄중위해인류건강，수연기발병궤제상미완전천명，단유흔다증거표명， AS시일충만성염증질병，재AS반괴적형성、진전、불은정성반괴파렬화혈전형성중염증기착비상중요작용。섭급도종류배사인자(TNF-α)、C-반응단백、동형반광안산、섬유단백매원、IL-6、IL-8、IL-18、IFN-γ、ICAM-1、MCP-1등，본문취염성인자재동맥죽양경화적형성급발전중적작용급궤제작일종술。
Atherosclerosis (AS) is a major pathological basis of cardiovascular disease, and cardiovascular disease, serious harm human health, although its pathogenesis has not been fully elucidated, but there are a lot of evidence that, AS is a chronic inflammatory disease in the AS plaque formation, progression, and unstable plaque rupture and thrombosis in inflammation plays a very important role. Involved in tumor necrosis factor (TNF alpha), C-reactive protein, homocysteine, fiber protease, IL-6 and IL 8, IL-18, IFN-γ, ICAM-1, MCP-1, etc., in this paper, the inflammatory cytokines in the role of the formation and development of atherosclerosis and mechanism.