CAJ | 학술논문

目的：观察不同维持剂量右旋美托咪啶(DEX)对机械通气患者心率和血压的影响。方法机械通气需要镇静的患者，静脉注射DEX负荷量1.0μg·kg-1，之后随机分为三组，A组以（0.2~0.7）μg·kg-1·h-1持续静脉泵入，B 组以（0.7~1.2）μg·kg-1·h-1持续静脉泵入，C 组以（1.2~1.7）μg·kg-1·h-1持续静脉泵入，观察镇静前、镇静后30 min的心率（HR）、平均动脉压（MAP）的变化情况。结果 A、B、C三组镇静后，HR较镇静前均有下降，差异有显著性,P <0.05；MAP较镇静前虽有下降，差异无显著性,P >0.05。结论增加DEX的维持剂量对患者循环功能无显著性影响。
목적：관찰불동유지제량우선미탁미정(DEX)대궤계통기환자심솔화혈압적영향。방법궤계통기수요진정적환자，정맥주사DEX부하량1.0μg·kg-1，지후수궤분위삼조，A조이（0.2~0.7）μg·kg-1·h-1지속정맥빙입，B 조이（0.7~1.2）μg·kg-1·h-1지속정맥빙입，C 조이（1.2~1.7）μg·kg-1·h-1지속정맥빙입，관찰진정전、진정후30 min적심솔（HR）、평균동맥압（MAP）적변화정황。결과 A、B、C삼조진정후，HR교진정전균유하강，차이유현저성,P <0.05；MAP교진정전수유하강，차이무현저성,P >0.05。결론증가DEX적유지제량대환자순배공능무현저성영향。
Objective To observe the effect of different dosage of dexmedetomidine on ventilated patients. Methods Ventilated patients who demanded sedation were administered intravenous injection of dexmedetomidine by the initial dose of 1.0μg·kg-1, then they were divided into three groups. A group patients were injected dexmedetomidine with the speed of 0.2~0.7μg·kg-1·h-1 using injecting pump, and those of B group and C group were injected dexmedetomidine with the speed of 0.7~1.2 μg·kg-1·h-1 and 1.2~1.7 μg·kg-1·h-1. The varieties of MAP and HR were observed before the sedation and after sedation 30 minutes. Results Comparing to before sedation, HR significantly decreased in three groups,P <0.05.after sedation 30 minutes, and though MAP dropped, it had not significant difference in three groups,P >0.05.after sedation 30 minutes. Conclusion The patients' circulation was not significant influenced by increasing dexmedetomidine dosages.