中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
6期
663-666
,共4页
盖俊峰%陈晓军%寇明捷%毛莉
蓋俊峰%陳曉軍%寇明捷%毛莉
개준봉%진효군%구명첩%모리
宫颈癌%癌前病变%危险因素
宮頸癌%癌前病變%危險因素
궁경암%암전병변%위험인소
Cervical cancer%Precancerous lesions%Risk factors
目的：对宫颈癌及癌前病变的相关危险因素进行分析研究，为相关理论研究提供信息。方法随机选取我院2010年6月至2013年6月经临床筛查确诊为宫颈癌患者30例、宫颈癌前病变（CIN）患者50例和健康查体者50名作为研究对象，宫颈癌和癌前病变患者共80例列入病变组，健康查体者50名列入对照组，比较两组研究对象人口统计学资料、生育史、性生活等情况。结果病变组与对照组各项危险因素：人乳头瘤病毒（HPV）感染阳性率分别为92.5％和4.0％（χ2=99.239，P <0.01），年龄>45岁比例分别为35.0％和16.0％（χ2=5.547，P <0.05）；文化程度高中及以下比例分别为82.5％和64.0％（χ2=5.675，P <0.05）；性生活时间≥3年比例分别为90.0％和72.0％（χ2=7.090，P <0.01）；产次≥2次比例分别为37.5％和20.0％（χ2=4.423，P <0.05）；流产次数≥2次比例分别为27.5％和12.0％（χ2=4.374，P <0.05）；不避孕比例分别为87.5％和72.0％（χ2=4.910，P <0.05）；不定期体检比例分别为77.5％和56.0％（χ2=6.676，P <0.01）；相关数据间比较差异均有统计学意义。结论 HPV感染、年龄、文化程度、性生活、产次、流产次数、避孕、定期检查等因素均为宫颈癌及癌前病变发生的危险因素，提倡妇女定期进行妇科体检，早期筛查和发现癌前病变，以提高宫颈癌的预防和早期干预效果。
目的：對宮頸癌及癌前病變的相關危險因素進行分析研究，為相關理論研究提供信息。方法隨機選取我院2010年6月至2013年6月經臨床篩查確診為宮頸癌患者30例、宮頸癌前病變（CIN）患者50例和健康查體者50名作為研究對象，宮頸癌和癌前病變患者共80例列入病變組，健康查體者50名列入對照組，比較兩組研究對象人口統計學資料、生育史、性生活等情況。結果病變組與對照組各項危險因素：人乳頭瘤病毒（HPV）感染暘性率分彆為92.5％和4.0％（χ2=99.239，P <0.01），年齡>45歲比例分彆為35.0％和16.0％（χ2=5.547，P <0.05）；文化程度高中及以下比例分彆為82.5％和64.0％（χ2=5.675，P <0.05）；性生活時間≥3年比例分彆為90.0％和72.0％（χ2=7.090，P <0.01）；產次≥2次比例分彆為37.5％和20.0％（χ2=4.423，P <0.05）；流產次數≥2次比例分彆為27.5％和12.0％（χ2=4.374，P <0.05）；不避孕比例分彆為87.5％和72.0％（χ2=4.910，P <0.05）；不定期體檢比例分彆為77.5％和56.0％（χ2=6.676，P <0.01）；相關數據間比較差異均有統計學意義。結論 HPV感染、年齡、文化程度、性生活、產次、流產次數、避孕、定期檢查等因素均為宮頸癌及癌前病變髮生的危險因素，提倡婦女定期進行婦科體檢，早期篩查和髮現癌前病變，以提高宮頸癌的預防和早期榦預效果。
목적：대궁경암급암전병변적상관위험인소진행분석연구，위상관이론연구제공신식。방법수궤선취아원2010년6월지2013년6월경림상사사학진위궁경암환자30례、궁경암전병변（CIN）환자50례화건강사체자50명작위연구대상，궁경암화암전병변환자공80례렬입병변조，건강사체자50명렬입대조조，비교량조연구대상인구통계학자료、생육사、성생활등정황。결과병변조여대조조각항위험인소：인유두류병독（HPV）감염양성솔분별위92.5％화4.0％（χ2=99.239，P <0.01），년령>45세비례분별위35.0％화16.0％（χ2=5.547，P <0.05）；문화정도고중급이하비례분별위82.5％화64.0％（χ2=5.675，P <0.05）；성생활시간≥3년비례분별위90.0％화72.0％（χ2=7.090，P <0.01）；산차≥2차비례분별위37.5％화20.0％（χ2=4.423，P <0.05）；유산차수≥2차비례분별위27.5％화12.0％（χ2=4.374，P <0.05）；불피잉비례분별위87.5％화72.0％（χ2=4.910，P <0.05）；불정기체검비례분별위77.5％화56.0％（χ2=6.676，P <0.01）；상관수거간비교차이균유통계학의의。결론 HPV감염、년령、문화정도、성생활、산차、유산차수、피잉、정기검사등인소균위궁경암급암전병변발생적위험인소，제창부녀정기진행부과체검，조기사사화발현암전병변，이제고궁경암적예방화조기간예효과。
Objective To investigate the risk factors of cervical cancer ane precancerous lesions,in oreer to proviee the basis for cervical cancer mechanism research. Methods Thirty cervical cancers,50 patients with cervical intraepithelial neoplasia( CIN)ane 50 healthy people were selectee as our subject who are eiagnosee from Jun. 2010 to Jun. 2013 in The Central Hospital of Binzhou. The lesion group inclueee 30 cervical cancers,50 CIN. Fifty healthy subjects were servee as the control group. The backgroune information inclueing eemographics,reproeuctive history,sex activities were collectee. Results Human papillomavirus (HPV)infection positive rate in lesion ane control group were 92. 5% ane 4. 0% ,respectively(χ2 = 99. 239, P < 0. 01). The ratio of age > 45 years in two group were 35. 0% ane 16. 0%(χ2 = 5. 547,P < 0. 05). The rate of eeucation below high school were 17. 5% ane 36. 0%(χ2 = 5. 675,P < 0. 05). Sexual perioes ≥ 3 years were 90. 0% ane 72. 0%(χ2 = 7. 090,P < 0. 01). The rate of proeuction times ≥ 2 times were 37. 5% ane 20. 0%(χ2 = 4. 423,P < 0. 05). The abortion rates ≥ 2 times were 27. 5% ane 12. 0%(χ2 = 4. 374,P < 0. 05). The non-contraception rates were 87. 5% ane 72. 0%(χ2 = 4. 910,P < 0. 05). Un-regular examination rates were 77. 5% ane 56. 0%( χ2 = 6. 676,P < 0. 01). There were significant eifferences between the relevant eata.Conclusion The factors inclueing HPV infection,age,eeucation level,sex,proeuction rate,number of abortions,contraception,ane un-regularly checkee are the risk factors of cervical precancerous lesions. The approaches such as women′ s regular gynecological examination,early cancer screening ane eiscovery precancerous lesions were provee to improve early intervention ane prevention of cervical cancer.
