CAJ | 학술논문

目的：分析视黄醇结合蛋白4（RB P4）在单纯2型糖尿病（对照组）及合并非酒精性脂肪肝的2型糖尿病患者（非酒精性脂肪肝组）血清定量，探讨RB P4与2型糖尿病患者非酒精性脂肪肝发生的相关性。方法65例2型糖尿病患者作为研究对象，其中30例患者（女18例，男12例）为合并非酒精性脂肪肝组，另外35例单纯2型糖尿病患者（女14例，男21例）作为对照组。腹部超声检查根据肝肾超声对比度和肝亮度对脂肪肝进行诊断。结果非酒精性脂肪肝组RBP4水平明显高于对照组（P＝0．017），多因素Logistic回归分析显示：血清RBP4是与非酒精性脂肪肝相关联的独立影响因子（P＝0．015，OR＝0．48），采用Pearson相关分析发现：RBP4水平与甘油三酯、低密度脂蛋白、谷丙转氨酶正相关，RBP4与高密度脂蛋白呈负相关。结论2型糖尿病患者中，RBP4与非酒精性肪肝的发生可能相关，可能成为2型糖尿病患者非酒精性脂肪肝的发生及进展的无创性预测因子。
목적：분석시황순결합단백4（RB P4）재단순2형당뇨병（대조조）급합병비주정성지방간적2형당뇨병환자（비주정성지방간조）혈청정량，탐토RB P4여2형당뇨병환자비주정성지방간발생적상관성。방법65례2형당뇨병환자작위연구대상，기중30례환자（녀18례，남12례）위합병비주정성지방간조，령외35례단순2형당뇨병환자（녀14례，남21례）작위대조조。복부초성검사근거간신초성대비도화간량도대지방간진행진단。결과비주정성지방간조RBP4수평명현고우대조조（P＝0．017），다인소Logistic회귀분석현시：혈청RBP4시여비주정성지방간상관련적독립영향인자（P＝0．015，OR＝0．48），채용Pearson상관분석발현：RBP4수평여감유삼지、저밀도지단백、곡병전안매정상관，RBP4여고밀도지단백정부상관。결론2형당뇨병환자중，RBP4여비주정성방간적발생가능상관，가능성위2형당뇨병환자비주정성지방간적발생급진전적무창성예측인자。
Objective The serum RBP4 was measured in non-alcoholic fatty liver disease (NAFLD)patients with type 2 diabetes mellitus (2DM ) and 2 DM patients without NAFLD .To in-vestigate the relationship between RBP4 and non-alcoholic fatty liver disease in type 2 diabetes mellitus adults .Methods Total of 65 patients with 2DM participated were studied .Division of the subjects in to a NALFD group (n=30 ;18 females and 12 males)or a control group (n=35 ,14 females and 21males) was based on the presence of fatty liver disease determined by sonography .Results Serum RBP4 levels in the NAFLD group were significantly higher than those in control of group (P<0 .05 ;P=0 .017) . Multiple logistic regression analysis revealed that the RBP4 levels was an independent factor associated with NALFD(P= 0 .015 ,OR=0 .48) .In addition ,the serum RBP4 levels were positively correlated with serum alanine aminotransferase(ALT) ,Triglyceride and LDL cholesterol .But the serum RBP4 levels were negatively related with HDL cholesterol by Pearson analysis .Conclusion Serum RBP4 might be related with the pathogeneses of NAFLD in patients with 2DM .Serum RBP4 might be the non-invasive predictive factor to the pathgensis and progression of NAFLD in 2DM patients .