CAJ | 학술논문

microRNA（miRNA）是一类含量丰富且高度保守的非编码小RNA分子，调控细胞分裂、分化、调亡等重要的生物学过程，并且在很多疾病中表达失调。miRNA在多种肿瘤的发生、发展中发挥重要作用。目前，对miRNA的研究正逐步从肿瘤分子研究走向临床应用领域，作为生物标志物用于癌症的诊断以及作为靶分子用于治疗已逐渐得到确认。本文对miRNA在胃癌中作为一个潜在的生物标志物用于诊断、预后、药物反应以及易感性的预测等方面的潜能进行综述。
microRNA（miRNA）시일류함량봉부차고도보수적비편마소RNA분자，조공세포분렬、분화、조망등중요적생물학과정，병차재흔다질병중표체실조。miRNA재다충종류적발생、발전중발휘중요작용。목전，대miRNA적연구정축보종종류분자연구주향림상응용영역，작위생물표지물용우암증적진단이급작위파분자용우치료이축점득도학인。본문대miRNA재위암중작위일개잠재적생물표지물용우진단、예후、약물반응이급역감성적예측등방면적잠능진행종술。
MicroRNAs (miRNA) are a class of small non-coding RNA molecules that are rich in content and are highly con-served. miRNA can regulate vital biological processes, including cell division, differentiation, and cell apoptosis. Their expression is dysregulated in many diseases. miRNA are essential in the initiation and development of various cancers. Recent miRNA studies have gradually moved from basic molecular studies of cancer onto areas of clinical application. The use of miRNA as biomarkers for cancer diagnosis and target molecules for cancer treatment is increasingly being identified. This review summarizes the potential applications of miRNA as biomarkers for diagnosis and prognosis of gastric cancer, drug response, and susceptibility prediction.