CAJ | 학술논문

目的：通过对食管鳞癌患者术前血浆D-二聚体水平和术后病理T、N分期的相关性做回顾性分析，探讨血浆D-二聚体水平与食管鳞癌恶性程度的关系。方法：选取本院2009年10月至2010年6月间101例无血液系统异常的食管鳞癌患者，对其术前血浆D-二聚体水平，术后病理T、N分期，组织学分级、转移N个数、肿瘤位置、肿瘤长径，病理分期等做统计学分析，探讨血浆D-二聚体水平与肿瘤转移、侵袭的关系。结果：术前血浆D-二聚体水平与病理组织学分级、肿瘤长径的相关性均无统计学意义（P>0.05）；而与T、N、TNM分期成正相关（P<0.05），并与阳性淋巴结枚数呈显著正相关（P<0.01）。此外，胸下段食管鳞癌患者术前血浆D-二聚体水平高于胸中上段者。结论：食管鳞癌患者D-二聚体水平与T、N、TNM分期、阳性淋巴结枚数成正相关，具有重要的临床意义。
목적：통과대식관린암환자술전혈장D-이취체수평화술후병리T、N분기적상관성주회고성분석，탐토혈장D-이취체수평여식관린암악성정도적관계。방법：선취본원2009년10월지2010년6월간101례무혈액계통이상적식관린암환자，대기술전혈장D-이취체수평，술후병리T、N분기，조직학분급、전이N개수、종류위치、종류장경，병리분기등주통계학분석，탐토혈장D-이취체수평여종류전이、침습적관계。결과：술전혈장D-이취체수평여병리조직학분급、종류장경적상관성균무통계학의의（P>0.05）；이여T、N、TNM분기성정상관（P<0.05），병여양성림파결매수정현저정상관（P<0.01）。차외，흉하단식관린암환자술전혈장D-이취체수평고우흉중상단자。결론：식관린암환자D-이취체수평여T、N、TNM분기、양성림파결매수성정상관，구유중요적림상의의。
Objective:To determine the relationship among tumor malignancy, invasion, and plasma D-dimer (DD) levels via a retrospective analysis of the correlation between preoperative plasma DD levels and postoperative pathology parameters in esophageal cancer patients. Methods:A total of 101 esophageal cancer patients without coagulation among preoperative plasma DD levels and postoperative pathology parameters in esophageal cancer patients who underwent radical operation between January 2009 to April 2010 were enrolled. The preoperative plasma DD levels, postoperative pathology T, N Grade, number of metastatic lymph nodes, tumor posi-tion, tumor length, and TNM stage were recorded. A statistic analysis of the above parameters was performed to reveal the correlation between plasma DD levels and tumor pathology features. Results:Preoperative plasma DD level has no correlation with Grade and tu-mor length, but shows positive correlation with pathology T, N status, and TNM stage, and has strong positive correlation with numbers of metastatic nodes. In addition, lower-third thoracic esophageal cancer patients have higher DD level than middle-third thoracic cases. Conclusion:Plasma DD level has a positive correlation with T stage, N stage, TNM stage, and number of positive lymph nodes. It also has important clinical significance.