中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
2013年
9期
895-897
,共3页
李月春%王东霞%李菜诗%叶镇彭%吴志明%陈建华
李月春%王東霞%李菜詩%葉鎮彭%吳誌明%陳建華
리월춘%왕동하%리채시%협진팽%오지명%진건화
结直肠肿瘤%5-脂氧合酶%免疫组织化学
結直腸腫瘤%5-脂氧閤酶%免疫組織化學
결직장종류%5-지양합매%면역조직화학
Colorectal neoplasms%5-Lipoxygenase%Immunohistochemistry
目的 探讨结直肠癌组织中5-脂氧合酶(5-LOX)的表达与患者临床病理因素的关系.方法 采用免疫组化SP法检测52例结直肠癌患者肿瘤组织中5-LOX的表达,分析5-LOX与结直肠癌患者临床病理因素的关系.结果 52例结直肠癌标本中,5-LOX表达阳性者38例(73.1％).5-LOX阳性表达率淋巴结转移组[87.8％(36/41)]高于无转移组[18.2％(2/11),P＜0.05],浸润较深组[T3～T4,81.1％(30/37)]高于浸润较浅组[T1～T2,53.3％(8/15),P＜0.05]；Ⅲ、Ⅳ期组[79.5％(31/39)]高于Ⅰ、Ⅱ期组[53.8％(7/13),P＜0.05]；低分化和未分化组[100％(24/24)]高于高、中分化组[50.0％(14/28),P＜0.05]；而肿瘤大小、脉管侵犯、腹膜转移与5-LOX阳性表达率无关.结论 5-LOX在结直肠癌组织中的阳性表达与肿瘤淋巴转移、浸润深度、分化程度和TNM分期有关.
目的 探討結直腸癌組織中5-脂氧閤酶(5-LOX)的錶達與患者臨床病理因素的關繫.方法 採用免疫組化SP法檢測52例結直腸癌患者腫瘤組織中5-LOX的錶達,分析5-LOX與結直腸癌患者臨床病理因素的關繫.結果 52例結直腸癌標本中,5-LOX錶達暘性者38例(73.1％).5-LOX暘性錶達率淋巴結轉移組[87.8％(36/41)]高于無轉移組[18.2％(2/11),P＜0.05],浸潤較深組[T3～T4,81.1％(30/37)]高于浸潤較淺組[T1～T2,53.3％(8/15),P＜0.05]；Ⅲ、Ⅳ期組[79.5％(31/39)]高于Ⅰ、Ⅱ期組[53.8％(7/13),P＜0.05]；低分化和未分化組[100％(24/24)]高于高、中分化組[50.0％(14/28),P＜0.05]；而腫瘤大小、脈管侵犯、腹膜轉移與5-LOX暘性錶達率無關.結論 5-LOX在結直腸癌組織中的暘性錶達與腫瘤淋巴轉移、浸潤深度、分化程度和TNM分期有關.
목적 탐토결직장암조직중5-지양합매(5-LOX)적표체여환자림상병리인소적관계.방법 채용면역조화SP법검측52례결직장암환자종류조직중5-LOX적표체,분석5-LOX여결직장암환자림상병리인소적관계.결과 52례결직장암표본중,5-LOX표체양성자38례(73.1％).5-LOX양성표체솔림파결전이조[87.8％(36/41)]고우무전이조[18.2％(2/11),P＜0.05],침윤교심조[T3～T4,81.1％(30/37)]고우침윤교천조[T1～T2,53.3％(8/15),P＜0.05]；Ⅲ、Ⅳ기조[79.5％(31/39)]고우Ⅰ、Ⅱ기조[53.8％(7/13),P＜0.05]；저분화화미분화조[100％(24/24)]고우고、중분화조[50.0％(14/28),P＜0.05]；이종류대소、맥관침범、복막전이여5-LOX양성표체솔무관.결론 5-LOX재결직장암조직중적양성표체여종류림파전이、침윤심도、분화정도화TNM분기유관.
Objective To examine the association of 5-lipoxygenase (5-LOX) expression with clinicopathological factors in colorectal cancer.Methods Immunohistochemical stain was used to detect the 5-LOX expression in 52 resected specimens of colorectal cancer.The association between 5-LOX expression and clinicopathological factors was examined.Results The positive rate of 5-LOX expression in 52 specimens of colorectal carcinoma was 73.1％ (38/52).In 41 colorectal cancer specimens with lymph node metastasis,the positive rate of 5-LOX expression was higher than that in the specimens without metastasis(87.8％ vs.18.2％,P＜0.05).The positive rate of 5-LOX expression in the specimens with deep infiltration (T3 and T4) was higher than that in the specimens with superficial infiltration(T1 and T2)(81.1％ vs.53.3％,P＜0.05).The positive rate of 5-LOX expression in TNM stage Ⅲ and Ⅳ cancer was higher than that in stage Ⅰ and Ⅱ (79.5％ vs.53.8％,P＜0.05).The positive rate of 5-LOX expression in cancers of poor differentiation and non-differentiation adenocarcinoma was higher than that of well and moderately differentiated cancer (100％ vs.50.0％,P＜0.05).There were no significant differences of 5-LOX expression with tumor size,vascular invasion and peritoneal dissemination.Conclusion 5-LOX expression in colorectal carcinoma is closely associated with lymph node metastasis,infiltration depth,differentiation degree and TNM stage.
