CAJ | 학술논문

目前外科手术已经成为治疗2型糖尿病治疗方式之一,但对于其治疗机制仍然还不明确.很多试验证明,糖尿病外科手术以后,解剖生理结构的改变导致了与代谢有关胃肠道分泌的激素和神经肽类分子水平的明显变化,这些分子在功能上与葡萄糖代谢、胰岛细胞功能、胰岛素敏感性相关,其中研究较为深入的是胰高血糖素样肽-1(gucagon-like peptide-1 GLP-1),其在外科手术治疗糖尿病中所起的重要作用已得到人们越来越多的认可.而GLP-1必须与GLP-1受体(GLP-1 receptor GLP-1R)结合后才能发挥其生理作用.本文就GLP-1及其受体在代谢外科手术治疗机制中的作用作一综述.
목전외과수술이경성위치료2형당뇨병치료방식지일,단대우기치료궤제잉연환불명학.흔다시험증명,당뇨병외과수술이후,해부생리결구적개변도치료여대사유관위장도분비적격소화신경태류분자수평적명현변화,저사분자재공능상여포도당대사、이도세포공능、이도소민감성상관,기중연구교위심입적시이고혈당소양태-1(gucagon-like peptide-1 GLP-1),기재외과수술치료당뇨병중소기적중요작용이득도인문월래월다적인가.이GLP-1필수여GLP-1수체(GLP-1 receptor GLP-1R)결합후재능발휘기생리작용.본문취GLP-1급기수체재대사외과수술치료궤제중적작용작일종술.
At present,surgery has become one of the treatments for type 2 diabetes,but it is still unclear about the therapeutic mechanism.Many experiments has proved that the anatomical and physiological structure has been altered leading to significant changes related to the secretion of gastrointestinal hormones and neuropeptides.These molecular are related to the metabolism of glucose,functions of islet cells and sensitivity of insulin.Intensive studies of glucagon-like peptide-1 (GLP-1) play an important role in the surgical treatment of diabetes and now it has gained increasing recognition.However,GLP-1 must be combined with GLP-1 receptor (GLP-1R) to execute its function.In this paper we reviewed the role of GLP-1 and its receptor in the mechanism of metabolic surgery.