中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2014年
7期
5-6
,共2页
七氟烷%丙泊酚%麻醉%老年肺癌%认知功能
七氟烷%丙泊酚%痳醉%老年肺癌%認知功能
칠불완%병박분%마취%노년폐암%인지공능
Wevoflurane%Propofol%Anesthesia%Lung cancer in elderly%Postoperative cognitive function
目的：探讨七氟烷和丙泊酚麻醉对老年肺癌患者术后认知功能的影响。方法回顾性分析2010年1月~2013年12月本院收治的106例老年肺癌患者的临床资料,随机将所有患者分为观察组和对照组,每组各53例,分别于术前12 h,术后6 h、12 h、1 d、3 d、7 d对两组的患者进行MMSE评分,麻醉前、术后及术后1 d取静脉血测定血清中的S100β蛋白浓度浓度。结果所有患者均顺利完成手术,术中的各生命体征平稳,两组患者的者年龄、体重、疾病构成等差异无统计学意义(P>0.05),术前MMSE评分及术前S100β蛋白差异无统计学意义(P>0.05)。术后两组的MMSE评分差异有统计学意义(P<0.05)。结论七氟烷与丙泊酚均可提高老年患者全身麻醉术后早期认知功能。但七氟烷与丙泊酚相比,术后认知功能障碍的发生率较低,恢复更快。
目的：探討七氟烷和丙泊酚痳醉對老年肺癌患者術後認知功能的影響。方法迴顧性分析2010年1月~2013年12月本院收治的106例老年肺癌患者的臨床資料,隨機將所有患者分為觀察組和對照組,每組各53例,分彆于術前12 h,術後6 h、12 h、1 d、3 d、7 d對兩組的患者進行MMSE評分,痳醉前、術後及術後1 d取靜脈血測定血清中的S100β蛋白濃度濃度。結果所有患者均順利完成手術,術中的各生命體徵平穩,兩組患者的者年齡、體重、疾病構成等差異無統計學意義(P>0.05),術前MMSE評分及術前S100β蛋白差異無統計學意義(P>0.05)。術後兩組的MMSE評分差異有統計學意義(P<0.05)。結論七氟烷與丙泊酚均可提高老年患者全身痳醉術後早期認知功能。但七氟烷與丙泊酚相比,術後認知功能障礙的髮生率較低,恢複更快。
목적：탐토칠불완화병박분마취대노년폐암환자술후인지공능적영향。방법회고성분석2010년1월~2013년12월본원수치적106례노년폐암환자적림상자료,수궤장소유환자분위관찰조화대조조,매조각53례,분별우술전12 h,술후6 h、12 h、1 d、3 d、7 d대량조적환자진행MMSE평분,마취전、술후급술후1 d취정맥혈측정혈청중적S100β단백농도농도。결과소유환자균순리완성수술,술중적각생명체정평은,량조환자적자년령、체중、질병구성등차이무통계학의의(P>0.05),술전MMSE평분급술전S100β단백차이무통계학의의(P>0.05)。술후량조적MMSE평분차이유통계학의의(P<0.05)。결론칠불완여병박분균가제고노년환자전신마취술후조기인지공능。단칠불완여병박분상비,술후인지공능장애적발생솔교저,회복경쾌。
Objective To compare the influence of sevoflurane and propfol anesthesia on the postoperative cognitive function in elder patients of lung cancer. Methods Retrospective analysis of clinical data in our hospital 106 cases of lung cancer of elderly patients from January 2010 to December 2013. All patients were randomly divided into 2 groups, Mini-mental state examination was conducted respectively at the time of 12 h preoperative, 6 h, 12 h, 1 d, 3 d, 7 d after the surgery. Blood samples were taken at before anesthesia, postoperative and 1 d after surgery, for the detection of serum concentration of S100β protein. Results All patients were successfully operated with stable vital signs of patients. In two groups, there was no significant difference of age, bodyweight, diseases ( P>0.05). There was no significant difference in preoperative MMSE grade and preoperative S100βprotein (P>0.05). MMSE grade after the two groups were statistically significant (P<0.05). Conclusion Propofol and sevoflurane can affect the early cognitive function in elderly patients after anesthesia and surgery. Compared with propofol, sevoflurane shows lower incidence rate of postoperative cognitive dysfunction and faster recovery.
