科技通报
科技通報
과기통보
BULLETIN OF SCIENCE AND TECHNOLOGY
2014年
2期
22-24,30
,共4页
陈锦龙%饶朗毓%陈灿%乔红秀
陳錦龍%饒朗毓%陳燦%喬紅秀
진금룡%요랑육%진찬%교홍수
两性霉素B%感染口腔%假丝酵母菌%失效性
兩性黴素B%感染口腔%假絲酵母菌%失效性
량성매소B%감염구강%가사효모균%실효성
amphotericin B%oral infection%candida%lose efficacy
目的:分析两性霉素B对医院口腔感染假丝酵母菌的失效性。方法:给予830例口腔感染患者两性霉素B治疗,初始3d的剂量是1、3、5 mg,加入5%葡萄糖溶液40 mg,保持速度是4 mL/h,从第4天开始每日增加4 mg,直至20 mg,后续保持该剂量;持续1~3个月的疗程,总用药量是1~1.5 g,并采用假丝酵母菌R因子检测方法分析两性霉素B对感染口腔假丝酵母菌的失效性。结果:从60株多重抗药性假丝酵母菌中分离出39株R因子,阳性率为65.5%,40株假丝酵母菌R因子的抗药性基因结构中3种以上抗药性基因者占有90%;结论:假丝酵母菌对两性霉素B的抗药性与传递R因子具有较强的关联性,利用R因子对两性霉素B对感染口腔假丝酵母菌失效性的分析具有安全和高效性的特征。
目的:分析兩性黴素B對醫院口腔感染假絲酵母菌的失效性。方法:給予830例口腔感染患者兩性黴素B治療,初始3d的劑量是1、3、5 mg,加入5%葡萄糖溶液40 mg,保持速度是4 mL/h,從第4天開始每日增加4 mg,直至20 mg,後續保持該劑量;持續1~3箇月的療程,總用藥量是1~1.5 g,併採用假絲酵母菌R因子檢測方法分析兩性黴素B對感染口腔假絲酵母菌的失效性。結果:從60株多重抗藥性假絲酵母菌中分離齣39株R因子,暘性率為65.5%,40株假絲酵母菌R因子的抗藥性基因結構中3種以上抗藥性基因者佔有90%;結論:假絲酵母菌對兩性黴素B的抗藥性與傳遞R因子具有較彊的關聯性,利用R因子對兩性黴素B對感染口腔假絲酵母菌失效性的分析具有安全和高效性的特徵。
목적:분석량성매소B대의원구강감염가사효모균적실효성。방법:급여830례구강감염환자량성매소B치료,초시3d적제량시1、3、5 mg,가입5%포도당용액40 mg,보지속도시4 mL/h,종제4천개시매일증가4 mg,직지20 mg,후속보지해제량;지속1~3개월적료정,총용약량시1~1.5 g,병채용가사효모균R인자검측방법분석량성매소B대감염구강가사효모균적실효성。결과:종60주다중항약성가사효모균중분리출39주R인자,양성솔위65.5%,40주가사효모균R인자적항약성기인결구중3충이상항약성기인자점유90%;결론:가사효모균대량성매소B적항약성여전체R인자구유교강적관련성,이용R인자대량성매소B대감염구강가사효모균실효성적분석구유안전화고효성적특정。
Objective:to analyze amphotericin B for hospital oral cavity infection of candida of failure. Method:830 cases of oral infection patients' amphotericin B therapy, the dose of initial 3 d is 1, 3, 5 mg and 40 mg in 5%glucose solution, maintain speed is 4 ml/h, starting from the fourth day on 4 mg per day, until 20 g, subsequent keep the dose; Last 1 to 3 months of treatment, the total dose is 1-1.5 g, and USES the candida R factor analysis of amphotericin B test method for the failure of oral candida infection. Results:from 60 strains of multidrug-resistant 39 strains of candida isolated R fac-tor, positive rate was 65.5%, 40 strains of candida R factor resistance gene structure of the above three kinds of resistant genes accounts for 90%; Candida. Conclusion:the resistance of amphotericin B with the transfer of R factor has strong correlation, by using R factor of amphotericin analysis of the failure of oral candida infection sex has the characteristics of safety and efficiency.